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Acute resveratrol s...
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Díaz, Miguel,HögskoleadjunktRöda Korsets Högskola,Hälsovetenskapliga institutionen,Manchester Metropolitan University, UK
(author)
Acute resveratrol supplementation in coronary artery disease : towards patient stratification
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2019-08-30
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Taylor & Francis,2020
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:rkh-3018
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https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-3018URI
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https://doi.org/10.1080/14017431.2019.1657584DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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OBJECTIVE: Resveratrol (RV) is a polyphenol with antioxidant, anti-inflammatory and cardio-protective properties. Our objective was to investigate whether acute supplementation with high doses of RV would improve flow-mediated dilation (FMD) and oxygen consumption (VO2) kinetics in older coronary artery disease (CAD) patients.DESIGN: We employed a placebo-controlled, single-blind, crossover design in which ten participants (aged 66.6 ± 7.8 years) received either RV or placebo (330 mg, 3x day-1) during three consecutive days plus additional 330 mg in the morning of the fourth day with a seven-day wash-out period in-between. On the fourth day, FMD of the brachial artery and VO2 on-kinetics were determined. Results; RV improved FMD in patients who had undergone coronary artery bypass grafting (CABG; -1.4 vs. 5.0%; p = 0.004), but not in those who had undergone percutaneous coronary intervention (PCI; 4.2 vs. -0.2%; NS).CONCLUSION: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients.
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Avila, AManchester Metropolitan University, UK / KU Leuven, Belgium
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Degens, HManchester Metropolitan University, UK / Lithuanian Sports University, Lithuania
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Coeckelberghs, EKU Leuven, Belgium
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Vanhees, LKU Leuven, Belgium
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Cornelissen, VKU Leuven, Belgium
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Azzawi, MManchester Metropolitan University, UK
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Röda Korsets HögskolaHälsovetenskapliga institutionen
(creator_code:org_t)
Related titles
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In:Scandinavian Cardiovascular Journal: Taylor & Francis:1, s. 14-191401-74311651-2006
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