The role of tryptophan and its derivatives in musculoskeletal pains: A systematic review and meta-analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Westman Julia) > The role of tryptop...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04032naa a2200457 4500
001		oai:DiVA.org:rkh-4878
003		SwePub
008		240613s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-48782 URI
024	7	a https://doi.org/10.1111/joor.137582 DOI
040		a (SwePub)rkh
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Canales, Giancarlo De La Torreu Karolinska Institutet, Sweden; Egas Moniz School of Health & Science, Portugal4 aut
245	1 0	a The role of tryptophan and its derivatives in musculoskeletal pains :b A systematic review and meta-analysis
264		c 2024
264	1	b John Wiley & Sons,c 2024
338		a print2 rdacarrier
520		a Background: Studies present ambiguous findings regarding the role of tryptophan and its metabolites, kynurenine and serotonin in chronic musculoskeletal pain. This systematic review aimed to investigate the expression of tryptophan and its metabolites, serotonin and kynurenine in patients with local and generalized chronic musculoskeletal pain in comparison with pain-free controls.Methods: An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to 21 April 2023. Out of 6734 articles, a total of 17 studies were included; 12 studies were used in the meta-analysis of serotonin, 3 regarding tryptophan and 2 studies for a narrative synthesis regarding kynurenine. Risk of bias was assessed using the quality assessment tool for observational cohort and cross-sectional studies of the National Heart, Lung, and Blood Institute, while the certainty of evidence was by GRADE.Results: All included studies showed a low risk of bias. The meta-analysis showed lower blood levels of tryptophan (p < .001; very low quality of evidence) and higher blood levels of serotonin (p < .001; very low-quality evidence) in patients with generalized musculoskeletal pain, when compared to pain-free individuals. In local chronic musculoskeletal pain, there were higher blood levels of serotonin (p=.251; very low quality of evidence) compared to pain-free individuals. Regarding kynurenine, the studies reported both higher and lower blood levels in generalized chronic musculoskeletal pain compared to pain-free individuals.Conclusions: The blood levels of tryptophan and its metabolites serotonin and kynurenine seem to influence chronic musculoskeletal pain.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a chronic musculoskeletal pain
653		a human
653		a kynurenine
653		a serotonin
653		a tryptophan
700	1	a Al-Moraissi, Essam Ahmedu Thamar University, Yemen4 aut
700	1	a Fatih, Tinau Karolinska Institutet, Sweden4 aut
700	1	a Razavian, Artinu Karolinska Institutet, Sweden4 aut
700	1	a Westman, Juliau Karolinska Institutet, Sweden4 aut
700	1	a Yanes, Yanalu Karolinska Institutet, Sweden4 aut
700	1	a Grigoriadis, Anastasiosu Karolinska Institutet, Sweden4 aut
700	1	a Christidis, Maria,d 1982-u Röda Korsets Högskola,Hälsovetenskapliga institutionen,Karolinska Institutet, Sweden4 aut0 (Swepub:rkh)chrm
700	1	a Christidis, Nikolaosu Karolinska Institutet, Sweden4 aut
700	1	a Barjandi, Golnazu Karolinska Institutet, Sweden4 aut
710	2	a Karolinska Institutet, Sweden; Egas Moniz School of Health & Science, Portugalb Thamar University, Yemen4 org
773	0	t Journal of Oral Rehabilitationd : John Wiley & Sonsx 1365-2842
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-4878
856	4 8	u https://doi.org/10.1111/joor.13758

Hitta via bibliotek

Journal of Oral Rehabilitation (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Canales, Giancar ...; Al-Moraissi, Ess ...; Fatih, Tina; Razavian, Artin; Westman, Julia; Yanes, Yanal; visa fler...; Grigoriadis, Ana ...; Christidis, Mari ...; Christidis, Niko ...; Barjandi, Golnaz; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Journal of Oral ...

Av lärosätet: Röda Korsets Högskola

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se