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Porsbjerg, Celeste M.Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark.,Bispebjerg Hospital
(författare)
Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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Frontiers Media S.A.2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-536701
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-536701URI
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https://doi.org/10.3389/fimmu.2024.1361891DOI
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https://lup.lub.lu.se/record/21ec4227-57fe-4d9a-aefa-ed6be3acbf69URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life.Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers.Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV1 for both anti-IgE and anti-IL5/5R, with a trend for antiI-IL4R alpha. Mean FEV1 improved by 27-178 mL post-anti-IgE as pre-biologic BEC increased (250 to 1000 cells/mu L), and by 43-216 mL and 129-250 mL post-anti-IL5/5R and - anti- IL4R alpha, respectively along the same BEC gradient. Corresponding improvements along a FeNO gradient (25-100 ppb) were 41-274 mL, 69-207 mL and 148-224 mL for anti-IgE, anti-IL5/5R, and anti-IL4R alpha, respectively. Higher baseline BEC was also associated with lower probability of uncontrolled asthma (OR 0.392; p=0.001) post-biologic for anti-IL5/5R. Pre-biologic IgE was a poor predictor of subsequent pre-to-post-biologic change for all outcomes assessed for all biologics. The combination of BEC + FeNO marginally improved the prediction of post-biologic FEV1 increase (adjusted R-2: 0.751), compared to BEC (adjusted R-2: 0.747) or FeNO alone (adjusted R-2: 0.743) (p=0.005 and <0.001, respectively); however, this prediction was not improved by the addition of IgE.Conclusions: The ability of higher baseline BEC, FeNO and their combination to predict biologic-associated lung function improvement may encourage earlier intervention in patients with impaired lung function or at risk of accelerated lung function decline.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Townend, JohnVancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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Bergeron, CelineMed Univ, Fac Publ Hlth, Sofia, Bulgaria.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
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Christoff, George C.Univ Notre Dame, Sch Med, Sydney Campus, Sydney, NSW, Australia.
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Katsoulotos, Gregory P.AstraZeneca, BioPharmaceut Med, Gaithersburg, MD USA.
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Larenas-Linnemann, DesireeKing Fahad Med, Dept Pulmonol, Riyadh, Saudi Arabia.
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Tran, Trung N.Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
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Al-Lehebi, RiyadMacquarie Univ, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
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Bosnic-Anticevich, Sinthia Z.Hosp Med, Ctr Excelencia Asma & Alergia, Mexico City, DF, Mexico.;Queens Univ Belfast, Sch Med, Ctr Publ Hlth, Dent & Biomed Sci, Belfast, Antrim, North Ireland.
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Busby, JohnAlfred Hlth, Allergy Asthma & Clin Immunol Serv, Melbourne, Vic, Australia.
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Hew, MarkMonash Univ, Publ Hlth & Prevent Med, Melbourne, Vic, Australia.;Univ Ioannina, Dept Resp Med, Ioannina, Greece.
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Kostikas, KonstantinosUniv Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England.
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Papadopoulos, Nikolaos G.Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece.;Barts Hlth Natl Hlth Serv NHS Trust, Dept Resp Med, London, England.
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Pfeffer, Paul E.Queen Mary Univ London, Barts & London Sch Med & Dent, London, England.;Univ Hosp St Ivan Rilski, Sofia, Bulgaria.;Catholic Univ Korea, Seoul St Marys Hosp, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea.
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Popov, Todor A.Univ British Columbia, Fac Pharmaceut Sci, Resp Evaluat Sci Program, Vancouver, BC, Canada.,Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
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Rhee, Chin KookKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung, Taiwan.
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Sadatsafavi, MohsenKaohsiung Med Univ, Sch Med, Coll Med, Dept Internal Med, Kaohsiung, Taiwan.
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Tsai, Ming-JuKuwait Univ, Dept Microbiol, Coll Med, Kuwait, Kuwait.
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Ulrik, Charlotte SuppliUniv Tartu & Lung Clin, Tartu Univ Hosp, Dept Pulmonol, Tartu, Estonia.
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Al-Ahmad, MonaInst Invest Sanitaria Illes Balears IdISB, Son Espases Univ Hosp, Mallorca, Spain.;Bispebjerg Hosp, Resp Res Unit, Copenhagen, Denmark.
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Altraja, AlanBispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.,Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Beastall, Aaron
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Bulathsinhala, Lakmini
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Carter, VictoriaVancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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Cosio, Borja G.Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland.
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Fletton, KirstyUniv British Columbia, Dept Med, Vancouver, BC, Canada.
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Hansen, SusanneUniv Nottingham, Resp Med Sch Med, Nottingham, England.
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Heaney, Liam G.Univ Nottingham, Resp Med Sch Med, Nottingham, England.
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Hubbard, Richard B.Med Univ Lodz, Div Internal Med Asthma & Allergy, Lodz, Poland.
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Kuna, PiotrKobe Univ, Grad Sch Med, Dept Internal Med, Div Resp Med, Kobe, Japan.
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Murray, Ruth B.Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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Nagano, TatsuyaUniv Brescia, Spedali Civili Brescia, Dept Clin & Expt Sci, Brescia, Italy.
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Pini, LauraInst Neumol Oriente, Bucaramanga, Colombia.
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Rosales, Diana Jimena CanoUniv Liege, Ctr Hosp Univ CHU Sart Tilman, GIGA I3, Liege, Belgium.
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Schleich, FlorenceUniv Liege, Liege, Belgium.
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Wechsler, Michael E.Natl Jewish Hlth NJH, Cohen Family Asthma Inst, Dept Med, Denver, CO USA.
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Amaral, RitaUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Univ Porto, CINTESIS RISE, MEDCIDS, Fac Med, Porto, Portugal.(Swepub:uu)ritam997
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Bourdin, ArnaudUniv Montpellier, Natl Inst Hlth & Med Res INSERM, Ctr Hosp Univ CHU Montpellier, Natl Ctr Sci Res CNRS, Montpellier, France.
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Brusselle, Guy G.Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands.
(författare)
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Chen, WenjiaNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
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Chung, Li PingFiona Stanley Hosp, Dept Resp Med, Perth, WA, Australia.
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Denton, EveMonash Univ, Cent Clin Sch, Med, Melbourne, Vic, Australia.
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Fonseca, Joao A.
(författare)
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Hoyte, FlaviaNatl Jewish Hlth, Dept Med, Div Allergy & Clin Immunol, Denver, CO USA.
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Jackson, David J.Kings Coll London, Guys Hosp, Guys Severe Asthma Ctr, London, England.
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Katial, Rohit
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Kirenga, Bruce J.Makerere Univ, Lung Inst, Dept Med, Kampala, Uganda.
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Koh, Mariko SiyueSingapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Lawkiedraj, AgnieszkaSingapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.;Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.
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Bjermer, L.Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups,Skåne University Hospital,Univ Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.(Swepub:lu)lung-lbj
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Liew, Mei FongTampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Natl Univ Hlth Syst, Alexandra Hosp, FAST & Chron Programmes, Singapore, Singapore.
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Mahboub, BassamNatl Univ Hlth Syst, Natl Univ Hosp, Dept Med, Div Resp & Crit Care Med, Singapore, Singapore.;Dubai Hlth Author DHA, Rashid Hosp, Dubai, U Arab Emirates.
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Martin, NeilDubai Acad & Hlth Corp, Dubai, U Arab Emirates.
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Menzies-Gow, Andrew N.Univ Leicester, Dept Resp Med, Leicester, Leics, England.;AstraZeneca, BioPharmaceut Med, Cambridge, England.
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Pang, Pee HweeRoyal Brompton & Harefield Hosp, Lung Div, London, England.
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Papaioannou, Andriana I.Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Patel, Pujan H.Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Perez-De-Llano, LuisAttikon Univ, Attikon Univ Hosp, Resp Med Dept 2, Athens, Greece.
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Peters, Matthew J.Royal Brompton Hosp, Resp Med, London, England.;Lucus Augusti Univ Hosp, Serv Pneumol, Sergas Galician Healthcare Serv Integrated Manage, Cervo, Spain.
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Ricciardi, LuisaConcord Hosp, Dept Thorac Med, Sydney, NSW, Australia.
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Rodriguez-Caceres, Bellanid
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Solarte, IvanMacquarie Univ, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Univ Messina, G Martino Hosp, Allergy & Clin Immunol, Messina, Italy.
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Tay, Tunn RenHosp Univ San Ignacio, Pulm Unit, Bogota, Colombia.
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Torres-Duque, Carlos A.Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Wang, Eileen
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Zappa, MartinaFdn Neumolo Colombiana, Resp Res Ctr, Ctr Internac Invest Neumol CINEUMO, Bogota, Colombia.
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Abisheganaden, JohnUniv La Sabana, Doctoral Biosci, Chia, Colombia.;Univ Colorado, Dept Med, Div Allergy & Clin Immunol, Sch Med, Aurora, CO USA.
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Assing, Karin DahlUniv Insubria, Dept Med & Surg, Varese, Italy.
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Costello, Richard W.Natl Healthcare Grp, Hlth Serv & Outcomes Res, Singapore, Singapore.
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Gibson, Peter G.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.;Aalborg Univ Hosp, Dept Resp Med, Aalborg, Denmark.
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Heffler, EnricoRoyal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
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Maspero, JorgeHunter Med Res Inst, John Hunter Hosp, Dept Resp & Sleep Med, Newcastle, NSW, Australia.;Humanitas Canc Ctr IRCCS Humanitas Res Hosp, Ist Clin Humanitas, Personalized Med Asthma & Allergy, Rozzano, Italy.
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Nicola, StefaniaHumanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy.
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Steve, Diahn-Warng PerngCIDEA Fdn, Clin Res Allergy & Resp Med, Buenos Aires, DF, Argentina.;Univ Buenos Aires, Univ Career Specialists Allergy & Clin Immunol, Allergy & Immunol Unit, Sch Med, Buenos Aires, DF, Argentina.
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Puggioni, Francesca
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Salvi, SundeepNatl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan.
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Sheu, Chau-Chyun
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Sirena, ConcettaTaipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.
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Taille, CamillePulmocare Res & Educ Fdn, Pune, Maharashtra, India.
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Tan, Tze LeeSevere Asthma Network Italy SANI, Milan, Italy.
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Bjermer, LeifUniv Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.
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Canonica, Giorgio WalterRoyal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
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Iwanaga, TakashiNatl Univ Hlth Syst, Dept Family Med, Singapore, Singapore.
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Jimenez-Maldonado, LibardoLund Univ, Skane Univ Hosp, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
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Taube, ChristianKindai Univ Hosp, Osakasayama, Japan.;Univ Turin, Dept Med Sci, Turin, Italy.
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Brussino, LuisaFdn Neumol Colombiana, ASMAIRE REXPIRA Atenc Integral & Rehabil Asma Or, Bogota, Colombia.;Univ Aberdeen, Ctr Acad Primary Care, Div Appl Hlth Sci, Aberdeen, Scotland.
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Price, David B.Univ Med Ctr Essen Ruhrlandklin, Dept Pulm Med, Essen, Germany.,Observational and Pragmatic Research Institute Pte Ltd,Optimum Patient Care Global,University of Aberdeen
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Lehtimaki, LauriUniv Lodz, Lodz, Poland.
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Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark.Bispebjerg Hospital
(creator_code:org_t)
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Sammanhörande titlar
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Ingår i:Frontiers in Immunology: Frontiers Media S.A.151664-3224
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Porsbjerg, Celes ...
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Townend, John
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Bergeron, Celine
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Christoff, Georg ...
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Katsoulotos, Gre ...
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Larenas-Linneman ...
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visa fler...
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Tran, Trung N.
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Al-Lehebi, Riyad
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Bosnic-Anticevic ...
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Busby, John
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Hew, Mark
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Kostikas, Konsta ...
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Papadopoulos, Ni ...
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Pfeffer, Paul E.
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Popov, Todor A.
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Rhee, Chin Kook
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Sadatsafavi, Moh ...
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Tsai, Ming-Ju
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Ulrik, Charlotte ...
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Al-Ahmad, Mona
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Altraja, Alan
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Beastall, Aaron
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Bulathsinhala, L ...
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Carter, Victoria
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Cosio, Borja G.
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Fletton, Kirsty
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Hansen, Susanne
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Heaney, Liam G.
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Hubbard, Richard ...
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Kuna, Piotr
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Murray, Ruth B.
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Nagano, Tatsuya
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Pini, Laura
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Rosales, Diana J ...
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Schleich, Floren ...
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Wechsler, Michae ...
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Amaral, Rita
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Bourdin, Arnaud
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Brusselle, Guy G ...
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Chen, Wenjia
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Chung, Li Ping
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Denton, Eve
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Fonseca, Joao A.
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Hoyte, Flavia
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Jackson, David J ...
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Katial, Rohit
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Kirenga, Bruce J ...
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Koh, Mariko Siyu ...
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Lawkiedraj, Agni ...
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Bjermer, L.
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Liew, Mei Fong
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Mahboub, Bassam
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Martin, Neil
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Menzies-Gow, And ...
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Pang, Pee Hwee
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Papaioannou, And ...
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Patel, Pujan H.
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Perez-De-Llano, ...
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Peters, Matthew ...
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Ricciardi, Luisa
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Rodriguez-Cacere ...
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Solarte, Ivan
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Tay, Tunn Ren
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Torres-Duque, Ca ...
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Wang, Eileen
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Zappa, Martina
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Abisheganaden, J ...
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Assing, Karin Da ...
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Costello, Richar ...
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Gibson, Peter G.
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Heffler, Enrico
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Maspero, Jorge
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Nicola, Stefania
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Steve, Diahn-War ...
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Puggioni, France ...
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Salvi, Sundeep
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Sheu, Chau-Chyun
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Sirena, Concetta
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Taille, Camille
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Tan, Tze Lee
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Bjermer, Leif
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Canonica, Giorgi ...
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Iwanaga, Takashi
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Jimenez-Maldonad ...
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Taube, Christian
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Brussino, Luisa
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Price, David B.
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Lehtimaki, Lauri
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