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Selection of cefoxi...
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Fang, HongKarolinska Institutet
(författare)
Selection of cefoxitin-resistant Bacteroides thetaiotaomicron mutants and mechanisms involved in beta-lactam resistance
- Artikel/kapitelEngelska2002
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Oxford University Press (OUP),2002
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:sh-17666
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https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-17666URI
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https://doi.org/10.1086/341920DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1959310URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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The beta-lactam antibiotics are the most widely used of all the groups of antimicrobials, but beta-lactam resistance is increasingly common among members of the Bacteroides fragilis group. Three major mechanisms are involved in beta-lactam resistance, and they act together in certain instances. In the present study, 2 resistant mutants (238m and 1186m) of Bacteroides thetaiotaomicron, obtained from clinical isolates (238 and 1186) by selection with increasing concentrations of cefoxitin, showed decreased susceptibilities to cefoxitin and other beta-lactam antibiotics. Alterations in both penicillin-binding proteins (PBPs) and outer-membrane proteins (OMPs) were observed in the mutants in comparison with their parent strains. The similar alteration in OMPs was also observed in clinical isolates. In conclusion, the beta-lactam-resistant mutants of B. thetaiotaomicron with deficiency in both PBPs and OMPs can be selected for by exposure to cefoxitin, and several mechanisms are involved in the beta-lactam resistance in the strains investigated.
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Edlund, CharlottaKarolinska Institutet,Södertörns högskola,Avdelning Naturvetenskap(Swepub:sh)SHCAED
(författare)
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Nord, C E
(författare)
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Hedberg, M
(författare)
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Karolinska InstitutetAvdelning Naturvetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Infectious Diseases: Oxford University Press (OUP)35, s. S47-S531058-48381537-6591
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