SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Allshire Robin)
 

Search: WFRF:(Allshire Robin) > (2007) > A NASP (N1/N2)-rela...

  • Dunleavy, Elaine M. (author)

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast Centromeres

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier BV,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:sh-22599
  • https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-22599URI
  • https://doi.org/10.1016/j.molcel.2007.10.010DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116428124URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp1) is specifically delivered to, and assembled into, centromeric chromatin. Through a screen for factors involved in kinetochore integrity in fission yeast, we identified Sim3. Sim3 is homologous to known histone binding proteins NASP(Human) and N1/N2(Xenopus) and aligns with Hif1(S. cerevisiae), defining the SHNi-TPR family. Sim3 is distributed throughout the nucleoplasm, yet it associates with CENP-A(Cnp1) and also binds H3. Cells defective in Sim3 function have reduced levels of CENP-A(CnP1) at centromeres (and increased H3) and display chromosome segregation defects. Sim3 is required to allow newly synthesized CENP-A(Cnp1) to accumulate at centromeres in S and G2 phase-arrested cells in a replication-independent mechanism. We propose that one function of Sim3 is to act as an escort that hands off CENP-A(Cnp1) to chromatin assembly factors, allowing its incorporation into centromeric chromatin.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pidoux, Alison L. (author)
  • Monet, Marie (author)
  • Bonilla, CarolinaKarolinska Institutet (author)
  • Richardson, William (author)
  • Hamilton, Georgina L. (author)
  • Ekwall, KarlKarolinska Institutet,Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institute (author)
  • McLaughlin, Paul J. (author)
  • Allshire, Robin C. (author)
  • Karolinska InstitutetInstitutionen för livsvetenskaper (creator_code:org_t)

Related titles

  • In:Molecular Cell: Elsevier BV28:6, s. 1029-10441097-27651097-4164

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view