SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Lind Lars)
 

Search: WFRF:(Lind Lars) > Smoking is associat...

  • Dumanski, Jan P.Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE) (author)

Smoking is associated with mosaic loss of chromosome Y

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:sh-25492
  • https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-25492URI
  • https://doi.org/10.1126/science.1262092DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239522URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-23384URI
  • https://research.hhs.se/esploro/outputs/journalArticle/Smoking-is-associated-with-mosaic-loss/991001480498706056URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rasi, ChiaraUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)(Swepub:uu)chira497 (author)
  • Lönn, MikaelSödertörns högskola,Biologi,Södertörn University, School of Life Sciences, Biology, Huddinge, Sweden,Södertörns högskola, Biologi,Södertörn University (SE)(Swepub:hig)millon (author)
  • Davies, HannaUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)(Swepub:uu)handa349 (author)
  • Ingelsson, MartinUppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)(Swepub:uu)maing121 (author)
  • Giedraitis, VilmantasUppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)(Swepub:uu)vigie517 (author)
  • Lannfelt, LarsKarolinska Institutet,Uppsala universitet,Geriatrik,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Uppsala University,Karolinska Institutet (SE),Uppsala University (SE)(Swepub:uu)lalan021 (author)
  • Magnusson, Patrik K EKarolinska Institutet,Department of Economics, Stockholm School of Economics, Stockholm, Sweden,Karolinska Institutet (SE) (author)
  • Lindgren, Cecilia MWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA,University of Oxford (GB) (author)
  • Morris, Andrew PWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Department of Biostatistics, University of Liverpool, Liverpool, UK,University of Oxford (GB) (author)
  • Cesarini, DavidCenter for Experimental Social Science, New York University, New York, NY 10012, USA (author)
  • Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se (author)
  • Tiensuu Janson, EvaUppsala universitet,Endokrin Onkologi,Uppsala University,Uppsala University (SE)(Swepub:uu)evatieja (author)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University(Swepub:uu)larslind (author)
  • Pedersen, Nancy LKarolinska Institutet (author)
  • Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University,Karolinska Institutet (SE)(Swepub:uu)ering425 (author)
  • Forsberg, Lars A.Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)(Swepub:uu)larfo354 (author)
  • Uppsala universitetMedicinsk genetik och genomik (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)347:6217, s. 81-830036-80751095-9203

Internet link

Find in a library

  • Science (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view