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Activation domain-m...
Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
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- Neely, K E (author)
- Pennsylvania State University, Pennsylvania, USA
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- Hassan, A H (author)
- Pennsylvania State University, Pennsylvania, USA
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- Wallberg, Annika E (author)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institutet
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- Steger, D J (author)
- Pennsylvania State University, Pennsylvania, USA
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- Cairns, B R (author)
- University of Utah School of Medicine, Salt Lake City, USA
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- Wright, Athony P H (author)
- Södertörns högskola,Avdelning Naturvetenskap,Karolinska Institutet
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- Workman, J L (author)
- Pennsylvania State University, Pennsylvania, USA
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Molecular Cell. - 1097-2765 .- 1097-4164. ; 4:4, s. 649-655
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The yeast SWI/SNF complex is required for the transcription of several yeast genes and has been shown to alter nucleosome structure in an ATP-dependent reaction. In this study, we show that the complex stimulated in vitro transcription from nucleosome templates in an activation domain-dependent manner. Transcription stimulation by SWI/SNF required an activation domain with which it directly interacts. The acidic activation domains of VP16, Gcn4, Swi5, and Hap4 interacted directly with the purified SWI/SNF complex and with the SWI/SNF complex in whole-cell extracts. The similarity of activation domain interactions and transcriptional stimulation between SWI/SNF and the SAGA histone acetyltransferase complex may account for their apparent overlapping functions in vivo.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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