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Long-term neurologi...
Long-term neurological and neurocognitive impairments after tick-borne encephalitis in Lithuania - a prospective study
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Griska, Vytautas (författare)
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Pranckeviciene, Aiste (författare)
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Pakalniene, Jolita (författare)
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visa fler...
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Gabrijolaviciute, Diana (författare)
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- Veje, Malin (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Studahl, Marie, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Ahlberg, Jacob (författare)
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Schwieler, Lilly (författare)
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Lindquist, Lars (författare)
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Mickiene, Aukse (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: INFECTIOUS DISEASES. - 2374-4235 .- 2374-4243.
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundThe aim of this study was to characterise long-term neurological and neurocognitive sequelae after tick-borne encephalitis (TBE) in adults.Methods98 prospective consecutive TBE patients, classified by disease severity, were included. Immediate outcomes were evaluated with Glasgow Outcome Scale (GOS) and Rankin Scale (RS). After 6 and 18 months, long-term disability was evaluated using Modified Rankin Scale (MRS) and neurocognitive assessment was performed with Matrics Consensus Cognitive Battery (MCCB), measuring processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning/problem solving and social cognition. The MCCB results were compared to healthy age, gender and education-matched controls.ResultsMild, moderate, and severe TBE was diagnosed in 53.1%, 38.8%, and 8.2% of cases, respectively. At discharge, 25.5% of the patients had major or moderate impairments (GOS) and various levels of disability in 34.7% (RS). Up to 18 months from the onset of TBE, over 20% remained with slight to moderate disability (MRS). GOS, RS and MRS scores correlated with disease severity. At 6 months after the onset, TBE patients scored significantly lower than controls in processing speed, verbal, and visual learning. Two latter domains were significantly more impaired in patients with mild TBE. Patients aged 18-39 performed significantly worse in attention/vigilance and working memory, whereas aged 60+ in verbal learning. A year later, significant improvement was observed in six of seven cognitive domains.ConclusionsLong-term neurological sequelae persist in a substantial proportion of TBE patients with significant impairment in several cognitive domains, especially in younger patients and even after mild TBE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Neuroinfection
- Post-encephalitic syndrome
- Neuropsychological testing
- Matrics Consensus Cognitive Battery
- Arbovirus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Griska, Vytautas
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Pranckeviciene, ...
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Pakalniene, Joli ...
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Gabrijolaviciute ...
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Veje, Malin
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Studahl, Marie, ...
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visa fler...
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Ahlberg, Jacob
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Schwieler, Lilly
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Lindquist, Lars
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Mickiene, Aukse
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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INFECTIOUS DISEA ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet