Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Lundquist Per) > Comparative effects...

Adamsson, IngerHuddinge University Hospital, Karolinska Institute, Stockholm, Sweden (författare)

Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients

Artikel/kapitelEngelska1999

Förlag, utgivningsår, omfång ...

1999-11
Nature Publishing Group,1999
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:sh-54378
https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-54378URI
https://doi.org/10.1093/jac/44.5.629DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1929621URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:11313203URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Fourteen patients with Helicobacter pylori infection were treated with 20 mg omeprazole, 1 g amoxycillin and 400 mg metronidazole bd for 7 days (OAM), and 16 patients were treated with 20 mg omeprazole, 250 mg clarithromycin and 400 mg metronidazole bd for 7 days (OCM). Saliva, gastric biopsies and faecal samples were collected before, during (day 7) and 4 weeks after treatment in order to analyse alterations of the normal microflora and to determine antimicrobial susceptibility. Both treatment regimens resulted in marked quantitative and qualitative alterations. A selection of resistant streptococcal strains were noticed in both treatment groups, most apparent in the OCM group where a shift from susceptible to resistant strains was recorded. In the OAM group, six patients had overgrowth of resistant Enterobacteriaceae during treatment compared with none in the OCM group, in the gastric microflora. The MICs for Enterococcus spp. and Enterobacteriaceae in faeces increased significantly during treatment in both groups. Nine patients in the OAM group became intestinally colonized by yeasts during treatment. The total anaerobic microflora was strongly suppressed in both treatment groups, although most pronounced in the OCM group, where the frequency of clarithromycin-resistant bacteroides strains increased from 2 to 76% during treatment, and remained at 59% 4 weeks post-treatment. Even if the treatment outcome was better in the OCM group (100%) than in the OAM group (71%), the amoxycillin-based treatment might be preferable from an ecological point of view, since the qualitative alterations in terms of emergence and persistence of resistant strains seemed to be most pronounced in the clarithromycin-treated group.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

Nord, Carl ErikKarolinska Institutet,Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden (författare)
Lundquist, PerHuddinge University Hospital, Karolinska Institute, Stockholm, Sweden (författare)
Sjöstedt, SvanteHuddinge University Hospital, Karolinska Institute, Stockholm, Sweden (författare)
Edlund, CharlottaKarolinska Institutet,Södertörns högskola,Avdelning Naturvetenskap,Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden(Swepub:sh)SHCAED (författare)
Karolinska InstitutetHuddinge University Hospital, Karolinska Institute, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Antimicrobial Chemotherapy: Nature Publishing Group45, s. A8-A80305-74531460-2091
Ingår i:GUT: Nature Publishing Group45, s. A8-A80017-5749

Internetlänk

Hitta via bibliotek

Journal of Antimicrobial Chemotherapy (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Adamsson, Inger; Nord, Carl Erik; Lundquist, Per; Sjöstedt, Svante; Edlund, Charlott ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

Artiklar i publikationen: Journal of Antim ...; GUT

Av lärosätet: Södertörns högskola; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se