Diabetes, Markers of Brain Pathology and Cognitive Function: The Age, Gene/Environment Susceptibility-Reykjavik Study

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Qiu, ChengxuanKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)

Diabetes, Markers of Brain Pathology and Cognitive Function : The Age, Gene/Environment Susceptibility-Reykjavik Study

Article/chapterEnglish2014

Publisher, publication year, extent ...

2014-02-12
Wiley,2014
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:su-102490
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102490URI
https://doi.org/10.1002/ana.24063DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:128419487URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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AuthorCount:11;Other funders:NIH/National Institute on Aging (NIA) N01-AG-12100 NIA, USA; Icelandic Heart Association; Icelandic Parliament, Iceland Swedish Research Council; Karolinska Institutet, Stockholm, Sweden
Objective: We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance. Methods: This cross-sectional study included 4,206 participants (age>65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Reykjavik Study. Data were collected through interview, clinical examination, psychological testing, and laboratory tests. The composite scores on memory, information-processing speed, and executive function were derived from a cognitive test battery. Markers of cerebral macrovascular (cortical infarcts), microvascular (subcortical infarcts, cerebral microbleeds, and higher white matter lesion volume), and neurodegenerative (lower gray matter, normal white matter, and total brain tissue volumes) processes were assessed on magnetic resonance images. Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders. Results: There were 462 (11.0%) persons with diabetes. Diabetes was significantly associated with lower scores on processing speed and executive function, but not with memory function. Diabetes was significantly associated with all markers of brain pathology. All of these markers were significantly associated with lower scores on memory, processing speed, and executive function. Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function. Interpretation: Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function. The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease. Older people with diabetes should be monitored for cognitive problems and brain lesions.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Sigurdsson, Sigurdur (author)
Zhang, Qian (author)
Jonsdottir, Maria K. (author)
Kjartansson, Olafur (author)
Eiriksdottir, Gudny (author)
Garcia, Melissa E. (author)
Harris, Tamara B. (author)
van Buchem, Mark A. (author)
Gudnason, Vilmundur (author)
Launer, Lenore J. (author)
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

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In:Annals of Neurology: Wiley75:1, s. 138-1460364-51341531-8249

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By the author/editor: Qiu, Chengxuan; Sigurdsson, Sigu ...; Zhang, Qian; Jonsdottir, Mari ...; Kjartansson, Ola ...; Eiriksdottir, Gu ...; show more...; Garcia, Melissa ...; Harris, Tamara B ...; van Buchem, Mark ...; Gudnason, Vilmun ...; Launer, Lenore J ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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By the university: Stockholm University; Karolinska Institutet

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