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Long-term Exposure to Air Pollution and Cardiovascular Mortality An Analysis of 22 European Cohorts

Beelen, Rob (author)
Stafoggia, Massimo (author)
Raaschou-Nielsen, Ole (author)
show more...
Andersen, Zorana Jovanovic (author)
Xun, Wei W. (author)
Katsouyanni, Klea (author)
Dimakopoulou, Konstantina (author)
Brunekreef, Bert (author)
Weinmayr, Gudrun (author)
Hoffmann, Barbara (author)
Wolf, Kathrin (author)
Samoli, Evangelia (author)
Houthuijs, Danny (author)
Nieuwenhuijsen, Mark (author)
Oudin, Anna (author)
Umeå universitet,Yrkes- och miljömedicin
Forsberg, Bertil (author)
Umeå universitet,Yrkes- och miljömedicin,Arcum
Olsson, David (author)
Umeå universitet,Yrkes- och miljömedicin
Salomaa, Veikko (author)
Lanki, Timo (author)
Yli-Tuomi, Tarja (author)
Oftedal, Bente (author)
Aamodt, Geir (author)
Nafstad, Per (author)
De Faire, Ulf (author)
Karolinska Institutet
Pedersen, Nancy L. (author)
Karolinska Institutet
Östenson, Claes-Göran (author)
Karolinska Institutet
Fratiglioni, Laura (author)
Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
Penell, Johanna (author)
Korek, Michal (author)
Karolinska Institutet
Pyko, Andrei (author)
Karolinska Institutet
Thorup Eriksen, Kirsten (author)
Tjonneland, Anne (author)
Becker, Thomas (author)
Eeftens, Marloes (author)
Bots, Michiel (author)
Meliefste, Kees (author)
Wang, Meng (author)
Bueno-de-Mesquita, Bas (author)
Sugiri, Dorothea (author)
Kraemer, Ursula (author)
Heinrich, Joachim (author)
de Hoogh, Kees (author)
Key, Timothy (author)
Peters, Annette (author)
Cyrys, Josef (author)
Concin, Hans (author)
Nagel, Gabriele (author)
Ineichen, Alex (author)
Schaffner, Emmanuel (author)
Probst-Hensch, Nicole (author)
Dratva, Julia (author)
Ducret-Stich, Regina (author)
Vilier, Alice (author)
Clavel-Chapelon, Francoise (author)
Stempfelet, Morgane (author)
Grioni, Sara (author)
Krogh, Vittorio (author)
Tsai, Ming-Yi (author)
Marcon, Alessandro (author)
Ricceri, Fulvio (author)
Sacerdote, Carlotta (author)
Galassi, Claudia (author)
Migliore, Enrica (author)
Ranzi, Andrea (author)
Cesaroni, Giulia (author)
Badaloni, Chiara (author)
Forastiere, Francesco (author)
Tamayo, Ibon (author)
Amiano, Pilar (author)
Dorronsoro, Miren (author)
Katsoulis, Michail (author)
Trichopoulou, Antonia (author)
Vineis, Paolo (author)
Hoek, Gerard (author)
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2014
2014
English.
In: Epidemiology. - : Lippincott Williams & Wilkins. - 1044-3983 .- 1531-5487. ; 25:3, s. 368-378
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE), we investigated the associations of long-term exposure to several air pollutants with all cardiovascular disease (CVD) mortality, as well as with specific cardiovascular causes of death. Methods: Data from 22 European cohort studies were used. Using a standardized protocol, study area-specific air pollution exposure at the residential address was characterized as annual average concentrations of the following: nitrogen oxides (NO2 and NOx); particles with diameters of less than 2.5 mu m (PM2.5), less than 10 mu m (PM10), and 10 mu m to 2.5 mu m (PMcoarse); PM2.5 absorbance estimated by land-use regression models; and traffic indicators. We applied cohort-specific Cox proportional hazards models using a standardized protocol. Random-effects meta-analysis was used to obtain pooled effect estimates. Results: The total study population consisted of 367,383 participants, with 9994 deaths from CVD (including 4,992 from ischemic heart disease, 2264 from myocardial infarction, and 2484 from cerebrovascular disease). All hazard ratios were approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 mu g/m(3) and for PM10, 1.22 (0.91-1.63) per 10 mu g/m(3). Conclusion: In a joint analysis of data from 22 European cohorts, most hazard ratios for the association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive evidence for an association.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

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By the author/editor
Beelen, Rob
Stafoggia, Massi ...
Raaschou-Nielsen ...
Andersen, Zorana ...
Xun, Wei W.
Katsouyanni, Kle ...
show more...
Dimakopoulou, Ko ...
Brunekreef, Bert
Weinmayr, Gudrun
Hoffmann, Barbar ...
Wolf, Kathrin
Samoli, Evangeli ...
Houthuijs, Danny
Nieuwenhuijsen, ...
Oudin, Anna
Forsberg, Bertil
Olsson, David
Salomaa, Veikko
Lanki, Timo
Yli-Tuomi, Tarja
Oftedal, Bente
Aamodt, Geir
Nafstad, Per
De Faire, Ulf
Pedersen, Nancy ...
Östenson, Claes- ...
Fratiglioni, Lau ...
Penell, Johanna
Korek, Michal
Pyko, Andrei
Thorup Eriksen, ...
Tjonneland, Anne
Becker, Thomas
Eeftens, Marloes
Bots, Michiel
Meliefste, Kees
Wang, Meng
Bueno-de-Mesquit ...
Sugiri, Dorothea
Kraemer, Ursula
Heinrich, Joachi ...
de Hoogh, Kees
Key, Timothy
Peters, Annette
Cyrys, Josef
Concin, Hans
Nagel, Gabriele
Ineichen, Alex
Schaffner, Emman ...
Probst-Hensch, N ...
Dratva, Julia
Ducret-Stich, Re ...
Vilier, Alice
Clavel-Chapelon, ...
Stempfelet, Morg ...
Grioni, Sara
Krogh, Vittorio
Tsai, Ming-Yi
Marcon, Alessand ...
Ricceri, Fulvio
Sacerdote, Carlo ...
Galassi, Claudia
Migliore, Enrica
Ranzi, Andrea
Cesaroni, Giulia
Badaloni, Chiara
Forastiere, Fran ...
Tamayo, Ibon
Amiano, Pilar
Dorronsoro, Mire ...
Katsoulis, Micha ...
Trichopoulou, An ...
Vineis, Paolo
Hoek, Gerard
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Occupational Hea ...
Articles in the publication
Epidemiology
By the university
Stockholm University
Umeå University
Karolinska Institutet

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