Search: id:"swepub:oai:DiVA.org:su-106632" >
The relationship be...
-
Goodman, AnnaStockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),London School of Hygiene and Tropical Medicine, UK
(author)
The relationship between umbilical cord length and chronic rheumatic heart disease : a prospective cohort study
- Article/chapterEnglish2015
Publisher, publication year, extent ...
-
2014-07-28
-
Oxford University Press (OUP),2015
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-106632
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-106632URI
-
https://doi.org/10.1177/2047487314544082DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:131784883URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: One previous, preliminary study reported that the length of the umbilical cord at birth is related to the risk of developing chronic rheumatic heart disease in later life. We sought to replicate this finding.DESIGN: Prospective, population-based birth cohort.METHODS: We traced 11,580 individuals born between 1915 and 1929 in Uppsala, Sweden. We identified cases with a main or secondary diagnosis of chronic rheumatic heart disease in the Swedish national inpatient, outpatient or death registers. Archived obstetric records provided data on umbilical cord length, gestational age, birthweight and placental weight.RESULTS: There were 136 patients with chronic rheumatic heart disease (72 men and 64 women) with a mean age at first hospital admission of 68 years (range 36-92). There was evidence of a positive association between umbilical cord length and risk of subsequent chronic rheumatic heart disease. The overall hazard ratio in the Swedish study (1.13, 95% confidence interval 1.01 to 1.27) was similar to that of the previous study, with some suggestion of larger effect in men than in women. No other birth characteristics were predictive except for weak evidence of a protective effect of higher birthweight in men.CONCLUSIONS: People with longer umbilical cords at birth are more likely to develop chronic rheumatic heart disease in later life. As longer umbilical cords have more spiral arteries and a higher vascular resistance, we hypothesize that the increased pressure load on the heart leads to changes in endothelial biology and increased vulnerability to the autoimmune process initiated by infection with β-haemolytic streptococci.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Kajantie, Eero
(author)
-
Osmond, Clive
(author)
-
Eriksson, Johan
(author)
-
Koupil, IlonaKarolinska Institutet,Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS)(Swepub:su)ikoup
(author)
-
Thornburg, Kent
(author)
-
Phillips, David IW
(author)
-
Stockholms universitetCentrum för forskning om ojämlikhet i hälsa (CHESS)
(creator_code:org_t)
Related titles
-
In:European Journal of Preventive Cardiology: Oxford University Press (OUP)22:9, s. 1154-11602047-48732047-4881
Internet link
Find in a library
To the university's database