Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness

Fager, MarcusStockholms universitet,Fysikum,University of Pennsylvania, Philadelphia (författare)

Linear energy transfer painting with proton therapy : a means of reducing radiation doses with equivalent clinical effectiveness

Purpose: The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LETd) while keeping the radiobiologically weighted dose (DRBE) to the target the same.Methods and Materials: The target is painted with LETd by using 2, 4, and 7 fields aimed at the proximal segment of the target (split target planning [STP]). As the LETd within the target increases with increasing number of fields, D decreases to maintain the DRBE the same as the conventional treatment planning method by using beams treating the full target (full target planning [FTP]).Results: The LETd increased 61% for 2-field STP (2STP) compared to FTP, 72% for 4STP, and 82% for 7STP inside the target. This increase in LETd led to a decrease of D with 5.3 ± 0.6 Gy for 2STP, 4.4 ± 0.7 Gy for 4STP, and 5.3 ± 1.1 Gy for 7STP, keeping the DRBE at 90% of the volume (DRBE, 90) constant to FTP.Conclusions: LETd painting offers a method to reduce prescribed dose at no cost to the biological effectiveness of the treatment.

Toma-Dasu, IulianaStockholms universitet,Fysikum,Karolinska Institutet, Sweden(Swepub:su)iuda0736 (författare)
Kirk, Maura (författare)
Dolney, Derek (författare)
Diffenderfer, Eric S. (författare)
Vapiwala, Neha (författare)
Carabe, Alejandro (författare)
Stockholms universitetFysikum (creator_code:org_t)

Ingår i:International Journal of Radiation Oncology, Biology, Physics: Elsevier BV91:5, s. 1057-10640360-30161879-355X

Av författaren/redakt...: Fager, Marcus; Toma-Dasu, Iulia ...; Kirk, Maura; Dolney, Derek; Diffenderfer, Er ...; Vapiwala, Neha; visa fler...; Carabe, Alejandr ...; visa färre...

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