Search: (WFRF:(Pedersen T.)) pers:(Grarup Niels) pers:(Lindgren Cecilia M.) >
Low-frequency and r...
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
-
Wessel, Jennifer (author)
-
Chu, Audrey Y. (author)
-
Willems, Sara M. (author)
-
show more...
-
Wang, Shuai (author)
-
Yaghootkar, Hanieh (author)
-
Brody, Jennifer A. (author)
-
Dauriz, Marco (author)
-
Hivert, Marie-France (author)
-
Raghavan, Sridharan (author)
-
Lipovich, Leonard (author)
-
Hidalgo, Bertha (author)
-
Fox, Keolu (author)
-
Huffman, Jennifer E. (author)
-
An, Ping (author)
-
Lu, Yingchang (author)
-
Rasmussen-Torvik, Laura J. (author)
-
Grarup, Niels (author)
-
Ehm, Margaret G. (author)
-
Li, Li (author)
-
- Baldridge, Abigail S. (author)
- Karolinska Institutet
-
Stancakova, Alena (author)
-
Abrol, Ravinder (author)
-
Besse, Celine (author)
-
Boland, Anne (author)
-
Bork-Jensen, Jette (author)
-
Fornage, Myriam (author)
-
Freitag, Daniel F. (author)
-
Garcia, Melissa E. (author)
-
Guo, Xiuqing (author)
-
Hara, Kazuo (author)
-
Isaacs, Aaron (author)
-
- Jakobsdottir, Johanna (author)
- Karolinska Institutet
-
Lange, Leslie A. (author)
-
Layton, Jill C. (author)
-
Li, Man (author)
-
Zhao, Jing Hua (author)
-
Meidtner, Karina (author)
-
Morrison, Alanna C. (author)
-
Nalls, Mike A. (author)
-
Peters, Marjolein J. (author)
-
- Sabater-Lleal, Maria (author)
- Karolinska Institutet
-
Schurmann, Claudia (author)
-
Silveira, Angela (author)
-
Smith, Albert V. (author)
-
Southam, Lorraine (author)
-
Stoiber, Marcus H. (author)
-
Strawbridge, Rona J. (author)
-
Taylor, Kent D. (author)
-
- V Varga, Tibor (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
- Allin, Kristine H. (author)
- Karolinska Institutet
-
Amin, Najaf (author)
-
Aponte, Jennifer L. (author)
-
Aung, Tin (author)
-
Barbieri, Caterina (author)
-
Bihlmeyer, Nathan A. (author)
-
Boehnke, Michael (author)
-
Bombieri, Cristina (author)
-
Bowden, Donald W. (author)
-
Burns, Sean M. (author)
-
Chen, Yuning (author)
-
Chen, Yii-Deri (author)
-
Cheng, Ching-Yu (author)
-
Correa, Adolfo (author)
-
Czajkowski, Jacek (author)
-
Dehghan, Abbas (author)
-
Ehret, Georg B. (author)
-
Eiriksdottir, Gudny (author)
-
Escher, Stefan A. (author)
-
Farmaki, Aliki-Eleni (author)
-
- Frånberg, Mattias (author)
- Stockholms universitet,Numerisk analys och datalogi (NADA),Science for Life Laboratory (SciLifeLab)
-
Gambaro, Giovanni (author)
-
Giulianini, Franco (author)
-
Goddard, William A., III (author)
-
Goel, Anuj (author)
-
Gottesman, Omri (author)
-
Grove, Megan L. (author)
-
- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Hai, Yang (author)
-
- Hallmans, Goeran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
-
Heo, Jiyoung (author)
-
Hoffmann, Per (author)
-
Ikram, Mohammad K. (author)
-
Jensen, Richard A. (author)
-
Jorgensen, Marit E. (author)
-
Jorgensen, Torben (author)
-
Karaleftheri, Maria (author)
-
Khor, Chiea C. (author)
-
Kirkpatrick, Andrea (author)
-
Kraja, Aldi T. (author)
-
Kuusisto, Johanna (author)
-
Lange, Ethan M. (author)
-
Lee, I. T. (author)
-
Lee, Wen-Jane (author)
-
Leong, Aaron (author)
-
Liao, Jiemin (author)
-
Liu, Chunyu (author)
-
Liu, Yongmei (author)
-
Lindgren, Cecilia M. (author)
-
Linneberg, Allan (author)
-
Malerba, Giovanni (author)
-
Mamakou, Vasiliki (author)
-
Marouli, Eirini (author)
-
Maruthur, Nisa M. (author)
-
Matchan, Angela (author)
-
McKean-Cowdin, Roberta (author)
-
McLeod, Olga (author)
-
Metcalf, Ginger A. (author)
-
Mohlke, Karen L. (author)
-
Muzny, Donna M. (author)
-
Ntalla, Ioanna (author)
-
Palmer, Nicholette D. (author)
-
Pasko, Dorota (author)
-
Peter, Andreas (author)
-
Rayner, Nigel W. (author)
-
- Renström, Frida (author)
- Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
Rice, Ken (author)
-
Sala, Cinzia F. (author)
-
Sennblad, Bengt (author)
-
Serafetinidis, Ioannis (author)
-
Smith, Jennifer A. (author)
-
Soranzo, Nicole (author)
-
Speliotes, Elizabeth K. (author)
-
Stahl, Eli A. (author)
-
Stirrups, Kathleen (author)
-
Tentolouris, Nikos (author)
-
Thanopoulou, Anastasia (author)
-
Torres, Mina (author)
-
Traglia, Michela (author)
-
Tsafantakis, Emmanouil (author)
-
Javad, Sundas (author)
-
Yanek, Lisa R. (author)
-
Zengini, Eleni (author)
-
Becker, Diane M. (author)
-
Bis, Joshua C. (author)
-
Brown, James B. (author)
-
Cupples, L. Adrienne (author)
-
Hansen, Torben (author)
-
- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Karter, Andrew J. (author)
-
Lorenzo, Carlos (author)
-
Mathias, Rasika A. (author)
-
Norris, Jill M. (author)
-
Peloso, Gina M. (author)
-
Sheu, Wayne H. -H. (author)
-
Toniolo, Daniela (author)
-
Vaidya, Dhananjay (author)
-
Varma, Rohit (author)
-
Wagenknecht, Lynne E. (author)
-
Boeing, Heiner (author)
-
Bottinger, Erwin P. (author)
-
Dedoussis, George (author)
-
Deloukas, Panos (author)
-
Ferrannini, Ele (author)
-
Franco, Oscar H. (author)
-
- Franks, Paul W. (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
Gibbs, Richard A. (author)
-
Gudnason, Vilmundur (author)
-
Hamsten, Anders (author)
-
Harris, Tamara B. (author)
-
Hattersley, Andrew T. (author)
-
Hayward, Caroline (author)
-
Hofman, Albert (author)
-
- Jansson, Jan-Håkan (author)
- Umeå universitet,Medicin
-
Langenberg, Claudia (author)
-
Launer, Lenore J. (author)
-
Levy, Daniel (author)
-
Oostra, Ben A. (author)
-
O'Donnell, Christopher J. (author)
-
O'Rahilly, Stephen (author)
-
Padmanabhan, Sandosh (author)
-
Pankow, James S. (author)
-
Polasek, Ozren (author)
-
Province, Michael A. (author)
-
Rich, Stephen S. (author)
-
Ridker, Paul M. (author)
-
Rudan, Igor (author)
-
Schulze, Matthias B. (author)
-
Smith, Blair H. (author)
-
Uitterlinden, Andre G. (author)
-
Walker, Mark (author)
-
Watkins, Hugh (author)
-
Wong, Tien Y. (author)
-
Zeggini, Eleftheria (author)
-
Laakso, Markku (author)
-
Borecki, Ingrid B. (author)
-
Chasman, Daniel I. (author)
-
Pedersen, Oluf (author)
-
Psaty, Bruce M. (author)
-
Tai, E. Shyong (author)
-
van Duijn, Cornelia M. (author)
-
Wareham, Nicholas J. (author)
-
Waterworth, Dawn M. (author)
-
Boerwinkle, Eric (author)
-
Kao, W. H. Linda (author)
-
Florez, Jose C. (author)
-
Loos, Ruth J. F. (author)
-
Wilson, James G. (author)
-
Frayling, Timothy M. (author)
-
Siscovick, David S. (author)
-
Dupuis, Josee (author)
-
Rotter, Jerome I. (author)
-
Meigs, James B. (author)
-
Scott, Robert A. (author)
-
Goodarzi, Mark O. (author)
-
Sharp, Stephen J. (author)
-
Forouhi, Nita G. (author)
-
Kerrison, Nicola D. (author)
-
Lucarelli, Debora M. E. (author)
-
Sims, Matt (author)
-
Barroso, Ines (author)
-
McCarthy, Mark I. (author)
-
Arriola, Larraitz (author)
-
Balkau, Beverley (author)
-
Barricarte, Aurelio (author)
-
Gonzalez, Carlos (author)
-
Grioni, Sara (author)
-
Kaaks, Rudolf (author)
-
Key, Timothy J. (author)
-
Navarro, Carmen (author)
-
Nilsson, Peter M. (author)
-
Overvad, Kim (author)
-
Palli, Domenico (author)
-
Panico, Salvatore (author)
-
Quiros, J. Ramon (author)
-
- Rolandsson, Olov (author)
- Umeå universitet,Enheten för biobanksforskning
-
Sacerdote, Carlotta (author)
-
Sanchez, Maria-Jose (author)
-
Slimani, Nadia (author)
-
Tjonneland, Anne (author)
-
Tumino, Rosario (author)
-
van der A, Daphne L. (author)
-
van der Schouw, Yvonne T. (author)
-
Riboli, Elio (author)
-
show less...
-
(creator_code:org_t)
- 2015-01-29
- 2015
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://www.nature.c...
-
https://umu.diva-por... (primary) (Raw object)
-
https://portal.resea... (primary) (free)
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF = 1.4%) with lower FG (beta = -0.09 +/- 0.01 mmol l(-1), P = 3.4 x 10(-12)), T2D risk (OR[95% CI] = 0.86[0.76-0.96], P = 0.010), early insulin secretion (beta = -0.07 +/- 0.035 pmol(insulin) mmol(glucose)(-1), P = 0.048), but higher 2-h glucose (beta = 0.16 +/- 0.05 mmol l(-1), P = 4.3 x 10(-4)). We identify a gene-based association with FG at G6PC2 (p(SKAT) = 6.8 x 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF = 20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (beta = 0.02 +/- 0.004 mmol l(-1), P = 1.3 x 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wessel, Jennifer
-
Chu, Audrey Y.
-
Willems, Sara M.
-
Wang, Shuai
-
Yaghootkar, Hani ...
-
Brody, Jennifer ...
-
show more...
-
Dauriz, Marco
-
Hivert, Marie-Fr ...
-
Raghavan, Sridha ...
-
Lipovich, Leonar ...
-
Hidalgo, Bertha
-
Fox, Keolu
-
Huffman, Jennife ...
-
An, Ping
-
Lu, Yingchang
-
Rasmussen-Torvik ...
-
Grarup, Niels
-
Ehm, Margaret G.
-
Li, Li
-
Baldridge, Abiga ...
-
Stancakova, Alen ...
-
Abrol, Ravinder
-
Besse, Celine
-
Boland, Anne
-
Bork-Jensen, Jet ...
-
Fornage, Myriam
-
Freitag, Daniel ...
-
Garcia, Melissa ...
-
Guo, Xiuqing
-
Hara, Kazuo
-
Isaacs, Aaron
-
Jakobsdottir, Jo ...
-
Lange, Leslie A.
-
Layton, Jill C.
-
Li, Man
-
Zhao, Jing Hua
-
Meidtner, Karina
-
Morrison, Alanna ...
-
Nalls, Mike A.
-
Peters, Marjolei ...
-
Sabater-Lleal, M ...
-
Schurmann, Claud ...
-
Silveira, Angela
-
Smith, Albert V.
-
Southam, Lorrain ...
-
Stoiber, Marcus ...
-
Strawbridge, Ron ...
-
Taylor, Kent D.
-
V Varga, Tibor
-
Allin, Kristine ...
-
Amin, Najaf
-
Aponte, Jennifer ...
-
Aung, Tin
-
Barbieri, Cateri ...
-
Bihlmeyer, Natha ...
-
Boehnke, Michael
-
Bombieri, Cristi ...
-
Bowden, Donald W ...
-
Burns, Sean M.
-
Chen, Yuning
-
Chen, Yii-Deri
-
Cheng, Ching-Yu
-
Correa, Adolfo
-
Czajkowski, Jace ...
-
Dehghan, Abbas
-
Ehret, Georg B.
-
Eiriksdottir, Gu ...
-
Escher, Stefan A ...
-
Farmaki, Aliki-E ...
-
Frånberg, Mattia ...
-
Gambaro, Giovann ...
-
Giulianini, Fran ...
-
Goddard, William ...
-
Goel, Anuj
-
Gottesman, Omri
-
Grove, Megan L.
-
Gustafsson, Stef ...
-
Hai, Yang
-
Hallmans, Goeran
-
Heo, Jiyoung
-
Hoffmann, Per
-
Ikram, Mohammad ...
-
Jensen, Richard ...
-
Jorgensen, Marit ...
-
Jorgensen, Torbe ...
-
Karaleftheri, Ma ...
-
Khor, Chiea C.
-
Kirkpatrick, And ...
-
Kraja, Aldi T.
-
Kuusisto, Johann ...
-
Lange, Ethan M.
-
Lee, I. T.
-
Lee, Wen-Jane
-
Leong, Aaron
-
Liao, Jiemin
-
Liu, Chunyu
-
Liu, Yongmei
-
Lindgren, Cecili ...
-
Linneberg, Allan
-
Malerba, Giovann ...
-
Mamakou, Vasilik ...
-
Marouli, Eirini
-
Maruthur, Nisa M ...
-
Matchan, Angela
-
McKean-Cowdin, R ...
-
McLeod, Olga
-
Metcalf, Ginger ...
-
Mohlke, Karen L.
-
Muzny, Donna M.
-
Ntalla, Ioanna
-
Palmer, Nicholet ...
-
Pasko, Dorota
-
Peter, Andreas
-
Rayner, Nigel W.
-
Renström, Frida
-
Rice, Ken
-
Sala, Cinzia F.
-
Sennblad, Bengt
-
Serafetinidis, I ...
-
Smith, Jennifer ...
-
Soranzo, Nicole
-
Speliotes, Eliza ...
-
Stahl, Eli A.
-
Stirrups, Kathle ...
-
Tentolouris, Nik ...
-
Thanopoulou, Ana ...
-
Torres, Mina
-
Traglia, Michela
-
Tsafantakis, Emm ...
-
Javad, Sundas
-
Yanek, Lisa R.
-
Zengini, Eleni
-
Becker, Diane M.
-
Bis, Joshua C.
-
Brown, James B.
-
Cupples, L. Adri ...
-
Hansen, Torben
-
Ingelsson, Erik
-
Karter, Andrew J ...
-
Lorenzo, Carlos
-
Mathias, Rasika ...
-
Norris, Jill M.
-
Peloso, Gina M.
-
Sheu, Wayne H. - ...
-
Toniolo, Daniela
-
Vaidya, Dhananja ...
-
Varma, Rohit
-
Wagenknecht, Lyn ...
-
Boeing, Heiner
-
Bottinger, Erwin ...
-
Dedoussis, Georg ...
-
Deloukas, Panos
-
Ferrannini, Ele
-
Franco, Oscar H.
-
Franks, Paul W.
-
Gibbs, Richard A ...
-
Gudnason, Vilmun ...
-
Hamsten, Anders
-
Harris, Tamara B ...
-
Hattersley, Andr ...
-
Hayward, Carolin ...
-
Hofman, Albert
-
Jansson, Jan-Håk ...
-
Langenberg, Clau ...
-
Launer, Lenore J ...
-
Levy, Daniel
-
Oostra, Ben A.
-
O'Donnell, Chris ...
-
O'Rahilly, Steph ...
-
Padmanabhan, San ...
-
Pankow, James S.
-
Polasek, Ozren
-
Province, Michae ...
-
Rich, Stephen S.
-
Ridker, Paul M.
-
Rudan, Igor
-
Schulze, Matthia ...
-
Smith, Blair H.
-
Uitterlinden, An ...
-
Walker, Mark
-
Watkins, Hugh
-
Wong, Tien Y.
-
Zeggini, Elefthe ...
-
Laakso, Markku
-
Borecki, Ingrid ...
-
Chasman, Daniel ...
-
Pedersen, Oluf
-
Psaty, Bruce M.
-
Tai, E. Shyong
-
van Duijn, Corne ...
-
Wareham, Nichola ...
-
Waterworth, Dawn ...
-
Boerwinkle, Eric
-
Kao, W. H. Linda
-
Florez, Jose C.
-
Loos, Ruth J. F.
-
Wilson, James G.
-
Frayling, Timoth ...
-
Siscovick, David ...
-
Dupuis, Josee
-
Rotter, Jerome I ...
-
Meigs, James B.
-
Scott, Robert A.
-
Goodarzi, Mark O ...
-
Sharp, Stephen J ...
-
Forouhi, Nita G.
-
Kerrison, Nicola ...
-
Lucarelli, Debor ...
-
Sims, Matt
-
Barroso, Ines
-
McCarthy, Mark I ...
-
Arriola, Larrait ...
-
Balkau, Beverley
-
Barricarte, Aure ...
-
Gonzalez, Carlos
-
Grioni, Sara
-
Kaaks, Rudolf
-
Key, Timothy J.
-
Navarro, Carmen
-
Nilsson, Peter M ...
-
Overvad, Kim
-
Palli, Domenico
-
Panico, Salvator ...
-
Quiros, J. Ramon
-
Rolandsson, Olov
-
Sacerdote, Carlo ...
-
Sanchez, Maria-J ...
-
Slimani, Nadia
-
Tjonneland, Anne
-
Tumino, Rosario
-
van der A, Daphn ...
-
van der Schouw, ...
-
Riboli, Elio
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Stockholm University
-
Umeå University
-
Lund University
-
Karolinska Institutet
-
Uppsala University