id:"swepub:oai:DiVA.org:su-115270"
Search: id:"swepub:oai:DiVA.org:su-115270" > Expression of GABA ...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Bhandage, Amol K.,1988-Uppsala universitet,Fysiologi,Bryndis Birnir,Department of Neuroscience; Uppsala University; Uppsala Sweden (author)
Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-01-21
- Wiley,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-115270
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115270URI
- https://doi.org/10.1111/apha.12440DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-240372URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480231URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- AuthorCount:6;
- AimThe concept of nerve-driven immunity recognizes a link between the nervous and the immune system. -aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, and receptors activated by GABA can be expressed by immune cells. Here, we examined whether the expression of GABA receptors and chloride transporters in human peripheral blood mononuclear cells (PBMCs) was influenced by gender, pregnancy or mental health. MethodsWe used RT-qPCR to determine the mRNA expression level in PBMCs from men (n=16), non-pregnant women (n=19), healthy pregnant women (n=27) and depressed pregnant women (n=15). ResultsThe 2 subunit had the most prominent expression level of the GABA-A receptor subunits in all samples. The and 2 subunits were up-regulated by pregnancy, whereas the epsilon subunit was more frequently expressed in healthy pregnant women than non-pregnant women who, in turn, commonly expressed the 6 and the 2 subunits. The 1 and epsilon subunits expression was altered by depression in pregnant women. The GABA-B1 receptor was up-regulated by depression in pregnant women, while the transporters NKCC1 and KCC4 were down-regulated by pregnancy. The changes recorded in the mRNA expression levels imply participation of GABA receptors in establishing and maintaining tolerance in pregnancy. Importantly, the correlation of mental health with the expression of specific receptor subunits reveals a connection between the immune cells and the brain. Biomarkers for mental health may be identified in PBMCs. ConclusionThe results demonstrate the impact gender, pregnancy and mental health have on the expression of GABA receptors and chloride transporters expressed in human PBMCs.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- depression
- GABA-A
- GABA-B
- NKCC1
- PBMC
- pregnancy
- Biologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Hellgren, CharlotteUppsala universitet,Obstetrik & gynekologi,Department of Women's and Children's Health; Uppsala University; Uppsala Sweden(Swepub:uu)chahe643 (author)
- Jin, ZheUppsala universitet,Fysiologi,Department of Neuroscience; Uppsala University; Uppsala Sweden(Swepub:uu)zheji315 (author)
- Olafsson, Einar B.Uppsala universitet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Institutionen för neurovetenskap,Fysiologi,Department of Neuroscience; Uppsala University; Uppsala Sweden;Department of Molecular Biosciences; Stockholm University; Stockholm Sweden(Swepub:uu)brybi979 (author)
- Sundström-Poromaa, IngerUppsala universitet,Obstetrik & gynekologi,Department of Women's and Children's Health; Uppsala University; Uppsala Sweden(Swepub:uu)inspo702 (author)
- Birnir, B. (author)
- Uppsala universitetFysiologi (creator_code:org_t)
Related titles
- In:Acta Physiologica: Wiley213:3, s. 575-5851748-17081748-1716
Internet link
Find in a library
- Acta Physiologica (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bhandage, Amol K ...
- Hellgren, Charlo ...
- Jin, Zhe
- Olafsson, Einar ...
- Sundström-Poroma ...
- Birnir, B.
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Physiology
- Articles in the publication
- Acta Physiologic ...
- By the university
- Stockholm University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
