Search: (WFRF:(Lambert D.)) srt2:(2015-2019)
> (2015) >
Genetic contributio...
Genetic contributions to variation in general cognitive function : a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
-
Davies, G. (author)
-
Armstrong, N. (author)
-
Bis, J. C. (author)
-
show more...
-
Bressler, J. (author)
-
Chouraki, V. (author)
-
Giddaluru, S. (author)
-
Hofer, E. (author)
-
Ibrahim-Verbaas, C. A. (author)
-
Kirin, M. (author)
-
Lahti, J. (author)
-
van der Lee, S. J. (author)
-
Le Hellard, S. (author)
-
Liu, T. (author)
-
Marioni, R. E. (author)
-
Oldmeadow, C. (author)
-
Postmus, I. (author)
-
Smith, A. V. (author)
-
Smith, J. A. (author)
-
Thalamuthu, A. (author)
-
Thomson, R. (author)
-
Vitart, V. (author)
-
Wang, J. (author)
-
Yu, L. (author)
-
Zgaga, L. (author)
-
Zhao, W. (author)
-
Boxall, R. (author)
-
Harris, S. E. (author)
-
Hill, W. D. (author)
-
Liewald, D. C. (author)
-
Luciano, M. (author)
-
Adams, H. (author)
-
Ames, D. (author)
-
Amin, N. (author)
-
Amouyel, P. (author)
-
Assareh, A. A. (author)
-
Au, R. (author)
-
Becker, J. T. (author)
-
Beiser, A. (author)
-
Berr, C. (author)
-
Bertram, L. (author)
-
Boerwinkle, E. (author)
-
Buckley, B. M. (author)
-
Campbell, H. (author)
-
Corley, J. (author)
-
De Jager, P. L. (author)
-
Dufouil, C. (author)
-
Eriksson, J. G. (author)
-
Espeseth, T. (author)
-
Faul, J. D. (author)
-
Ford, I. (author)
-
Gottesman, R. F. (author)
-
Griswold, M. E. (author)
-
Gudnason, V. (author)
-
Harris, T. B. (author)
-
Heiss, G. (author)
-
Hofman, A. (author)
-
Holliday, E. G. (author)
-
Huffman, J. (author)
-
Kardia, S. L. R. (author)
-
Kochan, N. (author)
-
Knopman, D. S. (author)
-
Kwok, J. B. (author)
-
Lambert, J-C (author)
-
Lee, T. (author)
-
Li, G. (author)
-
Li, S-C (author)
-
Loitfelder, M. (author)
-
Lopez, O. L. (author)
-
Lundervold, A. J. (author)
-
- Lundquist, Anders (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
-
Mather, K. A. (author)
-
Mirza, S. S. (author)
-
- Nyberg, Lars (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)
-
Oostra, B. A. (author)
-
Palotie, A. (author)
-
- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany
-
Pattie, A. (author)
-
Petrovic, K. (author)
-
Polasek, O. (author)
-
Psaty, B. M. (author)
-
Redmond, P. (author)
-
Reppermund, S. (author)
-
Rotter, J. I. (author)
-
Schmidt, H. (author)
-
Schuur, M. (author)
-
Schofield, P. W. (author)
-
Scott, R. J. (author)
-
Steen, V. M. (author)
-
Stott, D. J. (author)
-
Van Swieten, J. C. (author)
-
Taylor, K. D. (author)
-
Trollor, J. (author)
-
Trompet, S. (author)
-
Uitterlinden, A. G. (author)
-
Weinstein, G. (author)
-
Widen, E. (author)
-
Windham, B. G. (author)
-
Jukema, J. W. (author)
-
Wright, A. F. (author)
-
Wright, M. J. (author)
-
Yang, Q. (author)
-
Amieva, H. (author)
-
Attia, J. R. (author)
-
Bennett, D. A. (author)
-
Brodaty, H. (author)
-
de Craen, A. J. M. (author)
-
Hayward, C. (author)
-
Ikram, M. A. (author)
-
Lindenberger, U. (author)
-
- Nilsson, Lars-Göran (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),ARC, Karolinska Institutet, Stockholm
-
Porteous, D. J. (author)
-
Raikkonen, K. (author)
-
Reinvang, I. (author)
-
Rudan, I. (author)
-
Sachdev, P. S. (author)
-
Schmidt, R. (author)
-
Schofield, P. R. (author)
-
Srikanth, V. (author)
-
Starr, J. M. (author)
-
Turner, S. T. (author)
-
Weir, D. R. (author)
-
Wilson, J. F. (author)
-
Van Duijn, C. (author)
-
Launer, L. (author)
-
Fitzpatrick, A. L. (author)
-
Seshadri, S. (author)
-
Jr, T. H. Mosley (author)
-
Deary, I. J. (author)
-
show less...
-
(creator_code:org_t)
- 2015-02-03
- 2015
- English.
-
In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 20:2, s. 183-192
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://www.nature.c...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health-and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N = 53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P = 3.93 x 10(-9), MIR2113; rs17522122, P = 2.55 x 10(-8), AKAP6; rs10119, P = 5.67 x 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P = 1x10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N = 6617) and the Health and Retirement Study (N = 5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e. = 5%) and 28% (s.e. = 7%), respectively. Using polygenic prediction analysis, similar to 1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N = 5487; P = 1.5 x 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Davies, G.
-
Armstrong, N.
-
Bis, J. C.
-
Bressler, J.
-
Chouraki, V.
-
Giddaluru, S.
-
show more...
-
Hofer, E.
-
Ibrahim-Verbaas, ...
-
Kirin, M.
-
Lahti, J.
-
van der Lee, S. ...
-
Le Hellard, S.
-
Liu, T.
-
Marioni, R. E.
-
Oldmeadow, C.
-
Postmus, I.
-
Smith, A. V.
-
Smith, J. A.
-
Thalamuthu, A.
-
Thomson, R.
-
Vitart, V.
-
Wang, J.
-
Yu, L.
-
Zgaga, L.
-
Zhao, W.
-
Boxall, R.
-
Harris, S. E.
-
Hill, W. D.
-
Liewald, D. C.
-
Luciano, M.
-
Adams, H.
-
Ames, D.
-
Amin, N.
-
Amouyel, P.
-
Assareh, A. A.
-
Au, R.
-
Becker, J. T.
-
Beiser, A.
-
Berr, C.
-
Bertram, L.
-
Boerwinkle, E.
-
Buckley, B. M.
-
Campbell, H.
-
Corley, J.
-
De Jager, P. L.
-
Dufouil, C.
-
Eriksson, J. G.
-
Espeseth, T.
-
Faul, J. D.
-
Ford, I.
-
Gottesman, R. F.
-
Griswold, M. E.
-
Gudnason, V.
-
Harris, T. B.
-
Heiss, G.
-
Hofman, A.
-
Holliday, E. G.
-
Huffman, J.
-
Kardia, S. L. R.
-
Kochan, N.
-
Knopman, D. S.
-
Kwok, J. B.
-
Lambert, J-C
-
Lee, T.
-
Li, G.
-
Li, S-C
-
Loitfelder, M.
-
Lopez, O. L.
-
Lundervold, A. J ...
-
Lundquist, Ander ...
-
Mather, K. A.
-
Mirza, S. S.
-
Nyberg, Lars
-
Oostra, B. A.
-
Palotie, A.
-
Papenberg, Goran
-
Pattie, A.
-
Petrovic, K.
-
Polasek, O.
-
Psaty, B. M.
-
Redmond, P.
-
Reppermund, S.
-
Rotter, J. I.
-
Schmidt, H.
-
Schuur, M.
-
Schofield, P. W.
-
Scott, R. J.
-
Steen, V. M.
-
Stott, D. J.
-
Van Swieten, J. ...
-
Taylor, K. D.
-
Trollor, J.
-
Trompet, S.
-
Uitterlinden, A. ...
-
Weinstein, G.
-
Widen, E.
-
Windham, B. G.
-
Jukema, J. W.
-
Wright, A. F.
-
Wright, M. J.
-
Yang, Q.
-
Amieva, H.
-
Attia, J. R.
-
Bennett, D. A.
-
Brodaty, H.
-
de Craen, A. J. ...
-
Hayward, C.
-
Ikram, M. A.
-
Lindenberger, U.
-
Nilsson, Lars-Gö ...
-
Porteous, D. J.
-
Raikkonen, K.
-
Reinvang, I.
-
Rudan, I.
-
Sachdev, P. S.
-
Schmidt, R.
-
Schofield, P. R.
-
Srikanth, V.
-
Starr, J. M.
-
Turner, S. T.
-
Weir, D. R.
-
Wilson, J. F.
-
Van Duijn, C.
-
Launer, L.
-
Fitzpatrick, A. ...
-
Seshadri, S.
-
Jr, T. H. Mosley
-
Deary, I. J.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Molecular Psychi ...
- By the university
-
Stockholm University
-
Umeå University
-
Karolinska Institutet