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Influences of a DRD...
Influences of a DRD2 polymorphism on updating of long-term memory representations and caudate BOLD activity : magnification in aging
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- Persson, Jonas (författare)
- Karolinska Institutet,Umeå universitet,Stockholms universitet,Psykologiska institutionen,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center (ARC), Karolinska Institute and Stockholm University, Stockholm, Sweden; Department of Psychology, Stockholm University, Stockholm, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Karolinska Inst, ARC, S-11330 Stockholm, Sweden; Stockholm Univ, S-11330 Stockholm, Sweden; Stockholm Univ, Dept Psychol, S-11330 Stockholm, Sweden
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- Rieckmann, Anna (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
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- Kalpouzos, Grégoria (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center (ARC), Karolinska Institute and Stockholm University, Stockholm, Sweden
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- Fischer, Håkan (författare)
- Stockholms universitet,Psykologiska institutionen,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center (ARC), Karolinska Institute and Stockholm University, Gävlegatan 16, Stockholm, Sweden Department of Psychology, Stockholm University, Stockholm, Sweden
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- Bäckman, Lars (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center (ARC), Karolinska Institute and Stockholm University, Stockholm, Sweden
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(creator_code:org_t)
- 2014-12-09
- 2015
- Engelska.
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Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 36:4, s. 1325-1334
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Abstract
Ämnesord
Stäng
- A number of genetic polymorphisms are related to individual differences in cognitive performance. Striatal dopamine (DA) functions, associated with cognitive performance, are linked to the TaqIA polymorphism of the DRD2/ANKK1 gene. In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIA polymorphism is related to reduced density of striatal DA D2 receptors. The resource-modulation hypothesis assumes that aging-related losses of neurochemical and structural brain resources modulate the extent to which genetic variations affect cognitive functioning. Here, we tested this hypothesis using functional MRI during long-term memory (LTM) updating in younger and older carriers and noncarriers of the A1-allele of the TaqIa polymorphism. We demonstrate that older A1-carriers have worse memory performance, specifically during LTM updating, compared to noncarriers. Moreover, A1-carriers exhibited less blood oxygen level-dependent (BOLD) activation in left caudate nucleus, a region critical to updating. This effect was only seen in older adults, suggesting magnification of genetic effects on functional brain activity in aging. Further, a positive relationship between caudate BOLD activation and updating performance among non-A1 carriers indicated that caudate activation was behaviorally relevant. These results demonstrate a link between the DRD2/ANKK1-TaqIA polymorphism and neurocognitive deficits related to LTM updating, and provide novel evidence that this effect is magnified in aging.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- functional magnetic resonance imaging (fMRI)
- memory
- aging
- dopamine
- DRD2
- updating
- striatum
- psykologi
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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