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The human cardiac a...
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Lindskog, CeciliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
(author)
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-06-25
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Springer Science and Business Media LLC,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-118939
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-118939URI
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https://doi.org/10.1186/s12864-015-1686-yDOI
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https://research.chalmers.se/publication/219670URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-170959URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131467298URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258326URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20150713
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Background: To understand cardiac and skeletal muscle function, it is important to define and explore their molecular constituents and also to identify similarities and differences in the gene expression in these two different striated muscle tissues. Here, we have investigated the genes and proteins with elevated expression in cardiac and skeletal muscle in relation to all other major human tissues and organs using a global transcriptomics analysis complemented with antibody-based profiling to localize the corresponding proteins on a single cell level. Results: Our study identified a comprehensive list of genes expressed in cardiac and skeletal muscle. The genes with elevated expression were further stratified according to their global expression pattern across the human body as well as their precise localization in the muscle tissues. The functions of the proteins encoded by the elevated genes are well in line with the physiological functions of cardiac and skeletal muscle, such as contraction, ion transport, regulation of membrane potential and actomyosin structure organization. A large fraction of the transcripts in both cardiac and skeletal muscle correspond to mitochondrial proteins involved in energy metabolism, which demonstrates the extreme specialization of these muscle tissues to provide energy for contraction. Conclusions: Our results provide a comprehensive list of genes and proteins elevated in striated muscles. A number of proteins not previously characterized in cardiac and skeletal muscle were identified and localized to specific cellular subcompartments. These proteins represent an interesting starting point for further functional analysis of their role in muscle biology and disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Linne, JerkerUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
(author)
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Fagerberg, LinnKTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dglfid
(author)
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Hallström, Björn M.KTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ih19oh
(author)
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Sundberg, Carl JohanKarolinska Institutet
(author)
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Lindholm, MaleneKarolinska Institutet
(author)
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Huss, MikaelStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm University(Swepub:su)mihu5153
(author)
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Kampf, CarolineUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)carokamp
(author)
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Choi, HowardUniversity of California at Los Angeles (UCLA)
(author)
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Liem, David A.University of California at Los Angeles (UCLA)
(author)
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Ping, PeipeiUniversity of California at Los Angeles (UCLA)
(author)
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Varemo, Leif
(author)
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Mardinoglu, Adil,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)adilm
(author)
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Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
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Larsson, ErikUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)eriklars
(author)
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Pontén, FredrikUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)fredpont
(author)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw
(author)
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Wigge, Leif,1986Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)varemo
(author)
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Uppsala universitetScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
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In:BMC Genomics: Springer Science and Business Media LLC161471-2164
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Lindskog, Cecili ...
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Linne, Jerker
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Fagerberg, Linn
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Hallström, Björn ...
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Sundberg, Carl J ...
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Lindholm, Malene
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Huss, Mikael
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Kampf, Caroline
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Choi, Howard
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Liem, David A.
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Ping, Peipei
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Varemo, Leif
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Mardinoglu, Adil ...
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Nielsen, Jens B, ...
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Larsson, Erik
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Pontén, Fredrik
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Uhlén, Mathias
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Wigge, Leif, 198 ...
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NATURAL SCIENCES
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BMC Genomics
- By the university
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Stockholm University
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Chalmers University of Technology
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University