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- Abuzooda, ThanaStockholms universitet,Institutionen för analytisk kemi (author)
Graphite-based microextraction by packed sorbent for online extraction of beta-blockers from human plasma samples
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Elsevier BV,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-118963
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-118963URI
- https://doi.org/10.1016/j.jchromb.2015.04.027DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-271344URI
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- Language:English
- Summary in:English
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- In the present work a new graphitic material (Carbon-XCOS) was used as a sorbent for microextraction by packed sorbent (MEPS).The beta-blockers metoprolol and acebutolol in plasma samples were extracted and detected online using Carbon-MEPS syringe and liquid chromatography and tandem mass spectrometry (LC-MS/MS). Factors affecting the MEPS performance such as conditioning, washing and elution solutions were investigated. The validation of the bioanalytical method was performed using human plasma. The standard curve ranged from 10 to 2000 nM and the lower limit of quantification (LLOQ) was set to 10 nM. The method validation showed good accuracy and precision for the quality control (QC) samples at three concentration levels (30, 800 and 1600 nM). The accuracy values of the QC samples were in the range of 86-108% (n = 18). The precision values of intra- and inter-day for QC samples ranged from 4.4% to 14.4% (RSD) for the both studied analytes. The coefficient of determination (R-2) values were >= 0.999 (n = 3).
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- NATURVETENSKAP Kemi Analytisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Analytical Chemistry hsv//eng
- Graphitic sorbent
- Microextraction by packed sorbent
- beta-Blocker
- Plasma samples
Added entries (persons, corporate bodies, meetings, titles ...)
- Amini, AhmadSwedish Drug Agency,751 03 Uppsala, Sweden(Swepub:uu)aam09485 (author)
- Abdel-Rehim, MohamedStockholms universitet,Institutionen för analytisk kemi(Swepub:su)rabde (author)
- Stockholms universitetInstitutionen för analytisk kemi (creator_code:org_t)
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- In:Journal of chromatography. B: Elsevier BV992, s. 86-901570-02321873-376X
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