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Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics

Sonavane, Sumalata (författare)
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.,Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.
Hassan, Sameer (författare)
Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Huddinge, Sweden.,Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
Chatterjee, Urmimala (författare)
Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Huddinge, Sweden.,Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
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Soler, Lucile (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
Holm, Lena (författare)
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.,Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.
Mollbrink, Annelie (författare)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Department of Gene Technology, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden,KTH Royal Inst Technol, Dept Gene Technol, SciLifeLab, Stockholm, Sweden.
Greco, Gabriele (författare)
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.,Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.
Fereydouni, Noah (författare)
Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Huddinge, Sweden.,Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
Vinnere Pettersson, Olga (författare)
Department of Immunology, Genetics and Pathology, National Genomics Infrastructure, SciLifeLab, Uppsala, Sweden.,Natl Genom Infrastruct, Dept Immunol Genet & Pathol, SciLifeLab, Uppsala, Sweden.
Bunikis, Ignas (författare)
Department of Immunology, Genetics and Pathology, National Genomics Infrastructure, SciLifeLab, Uppsala, Sweden.,Natl Genom Infrastruct, Dept Immunol Genet & Pathol, SciLifeLab, Uppsala, Sweden.
Churcher, Allison M (författare)
Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Molecular Biology, NBIS, SciLifeLab, Umeå University, Umeå, Sweden.,Umeå Univ, Dept Mol Biol, NBIS, SciLifeLab, Umeå, Sweden.
Lantz, Henrik (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
Johansson, Jan (författare)
Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Huddinge, Sweden.,Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
Reimegård, Johan (författare)
Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
Rising, Anna (författare)
Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.;Department of Biosciences and Nutrition, Karolinska Institutet, Neo, Huddinge, Sweden.,Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.;Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
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Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden. (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2024
2024
Engelska.
Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 10:33
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Spiders produce nature’s toughest fiber using renewable components at ambient temperatures and with water as solvent, making it highly interesting to replicate for the materials industry. Despite this, much remains to be understood about the bioprocessing and composition of spider silk fibers. Here, we identify 18 proteins that make up the spiders’ strongest silk type, the major ampullate fiber. Single-cell RNA sequencing and spatial transcriptomics revealed that the secretory epithelium of the gland harbors six cell types. These cell types are confined to three distinct glandular zones that produce specific combinations of silk proteins. Image analysis of histological sections showed that the secretions from the three zones do not mix, and proteomics analysis revealed that these secretions form layers in the final fiber. Using a multi-omics approach, we provide substantial advancements in the understanding of the structure and function of the major ampullate silk gland as well as of the architecture and composition of the fiber it produces.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

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