Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis: Findings from the Betula Longitudinal Study

Boraxbekk, Carl-Johan,1980-Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR) (author)

Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis : Findings from the Betula Longitudinal Study

Background/Aims: Early dementia diagnosis is a considerable challenge. The present study examined the predictive value of cognitive performance for a future clinical diagnosis of late-onset Alzheimer's disease or vascular dementia in a random population sample. Methods: Cognitive performance was retrospectively compared between three groups of participants from the Betula longitudinal cohort. Group 1 developed dementia 11-22 years after baseline testing (n = 111) and group 2 after 1-10 years (n = 280); group 3 showed no deterioration towards dementia during the study period (n = 2,855). Multinomial logistic regression analysis was used to investigate the predictive value of tests reflecting episodic memory performance, semantic memory performance, visuospatial ability, and prospective memory performance. Results: Age-and education-corrected performance on two free recall episodic memory tests significantly predicted dementia 10 years prior to clinical diagnosis. Free recall performance also predicted dementia 11-22 years prior to diagnosis when controlling for education, but not when age was added to the model. Conclusion: The present results support the suggestion that two free recall-based tests of episodic memory function may be useful for detecting individuals at risk of developing dementia 10 years prior to clinical diagnosis.

Lundquist, AndersUmeå universitet,Statistik(Swepub:umu)anslst97 (author)
Nordin, AnnelieUmeå universitet,Psykiatri(Swepub:umu)anenon01 (author)
Nyberg, LarsUmeå universitet,Fysiologi,Diagnostisk radiologi(Swepub:umu)lany0001 (author)
Nilsson, Lars-GöranStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institutet (author)
Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
Umeå universitetEnheten för demografi och åldrandeforskning (CEDAR) (creator_code:org_t)

In:Dementia and Geriatric Cognitive Disorders Extra: S. Karger AG5:2, s. 191-2021664-5464

By the author/editor: Boraxbekk, Carl- ...; Lundquist, Ander ...; Nordin, Annelie; Nyberg, Lars; Nilsson, Lars-Gö ...; Adolfsson, Rolf

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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