Search: id:"swepub:oai:DiVA.org:su-127864" >
Dynamic niche-speci...
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Liu, YanInner Mongolia Univ Nationalities, Sch Life Sci, Tongliao 028000, Peoples R China.
(author)
Dynamic niche-specific adaptations in Neisseria meningitidis during infection
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier BV,2016
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LIBRIS-ID:oai:DiVA.org:su-127864
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-127864URI
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https://doi.org/10.1016/j.micinf.2015.09.025DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281966URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Neisseria meningitidis is an opportunistic human pathogen that usually colonizes the nasopharyngeal mucosa asymptomatically. Upon invasion into the blood and central nervous system, this bacterium triggers a fulminant inflammatory reaction with the manifestations of septicemia and meningitis, causing high morbidity and mortality. To reveal the bacterial adaptations to specific and dynamic host environments, we performed a comprehensive proteomic survey of N. meningitidis isolated from the nasal mucosa, CSF and blood of a mouse disease model. We could identify 51 proteins whose expression pattern has been changed during infection, many of which have not yet been characterized. The abundance of proteins was markedly lower in the bacteria isolated from the nasal mucosa compared to the bacteria from the blood and CSF, indicating that initiating adhesion is the harshest challenge for meningococci. The high abundance of the glutamate dehydrogenase (GdhA) and Opa1800 proteins in all bacterial isolates suggests their essential role in bacterial survival in vivo. To evaluate the biological relevance of our proteomic findings, four candidate proteins from representative functional groups, such as the bacterial chaperone GroEL, IMP dehydrogenase GuaB, and membrane proteins PilQ and NMC0101, were selected and their impact on bacterial fitness was investigated by mutagenesis assays. This study provides an integrated picture of bacterial niche-specific adaptations during consecutive infection processes.
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Zhang, DingStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.;Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China.;Kitasato Univ, Grad Sch Infect Control Sci, Tokyo 1088641, Japan.
(author)
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Engström, ÅkeUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)akeengs
(author)
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Merényi, GáborStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Hagner, MatthiasStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Yang, HairuStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Kuwae, AsaomiStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Wan, YiStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Sjölinder, MikaelStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
(author)
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Sjölinder, HongStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.(Swepub:su)hwan
(author)
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Inner Mongolia Univ Nationalities, Sch Life Sci, Tongliao 028000, Peoples R China.Institutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Microbes and infection: Elsevier BV18:2, s. 109-1171286-45791769-714X
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Liu, Yan
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Zhang, Ding
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Engström, Åke
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Merényi, Gábor
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Hagner, Matthias
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Yang, Hairu
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Kuwae, Asaomi
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Wan, Yi
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Sjölinder, Mikae ...
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Sjölinder, Hong
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