Sökning: L773:1095 9130 OR L773:1046 2023 >
Bispecific applicat...
Bispecific applications of non-immunoglobulin scaffold binders
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- Hober, Sophia, 1965- (författare)
- KTH,Proteinvetenskap
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- Lindbo, Sarah (författare)
- KTH,Proteinteknologi
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- Nilvebrant, Johan, 1982- (författare)
- KTH,Proteinvetenskap
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
- 2019
- Engelska.
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Ingår i: Methods. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1046-2023 .- 1095-9130. ; 154, s. 143-152
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Non-immunoglobulin scaffolds represent a proven group of small affinity proteins that can be engineered in vitro to similar affinity and potency as monoclonal antibodies. Several novel candidate biotherapeutics that exploit the potential advantages scaffold proteins hold over larger and more complex antibodies have been developed over the past decade. The ease of using small and robust binding proteins as flexible and modular building blocks has led to the development of a wide range of innovative approaches to combine them in various bi- and multispecific formats. This progress is expected to aid the ongoing challenge of identifying niche applications where clear differentiation from antibody-based molecules will be key to success. Given the many engineering options that are available for non-immunoglobulin scaffold proteins, they have potential to not only complement but probably also surpass antibodies in certain applications.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Annan industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Other Industrial Biotechnology (hsv//eng)
Nyckelord
- Non-immunoglobulin scaffold
- In vitro evolution
- Protein engineering
- Bispecific
- Biparatopic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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