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Sökning: WFRF:(Chiotis Konstantinos) > Imaging in-vivo tau...

  • Chiotis, KonstantinosKarolinska Institutet (författare)

Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-03-21
  • Springer Science and Business Media LLC,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-132930
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-132930URI
  • https://doi.org/10.1007/s00259-016-3363-zDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281916URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133861771URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose The aim of this study was to explore the cerebral distribution of the tau-specific PET tracer [F-18]THK5317 (also known as (S)-[F-18]THK5117) retention in different stages of Alzheimer's disease; and study any associations with markers of hypometabolism and amyloid-beta deposition. Methods Thirty-three individuals were enrolled, including nine patients with Alzheimer's disease dementia, thirteen with mild cognitive impairment (MCI), two with non-Alzheimer's disease dementia, and nine healthy controls (five young and four elderly). In a multi-tracer PET design [F-18]THK5317, [C-11] Pittsburgh compound B ([C-11]PIB), and [F-18]FDG were used to assess tau pathology, amyloid-beta deposition and cerebral glucose metabolism, respectively. The MCI patients were further divided into MCI [C-11]PIB-positive (n=11) and MCI [C-11]PIB-negative (n=2) groups. Results Test-retest variability for [F-18]THK5317-PET was very low (1.17-3.81 %), as shown by retesting five patients. The patients with prodromal (MCI [C-11]PIB-positive) and dementia-stage Alzheimer's disease had significantly higher [F-18]THK5317 retention than healthy controls (p=0.002 and p=0.001, respectively) in areas exceeding limbic regions, and their discrimination from this control group (using the area under the curve) was >98 %. Focal negative correlations between [F-18]THK5317 retention and [F-18]FDG uptake were observed mainly in the frontal cortex, and focal positive correlations were found between [F-18]THK5317 and [C-11] PIB retentions isocortically. One patient with corticobasal degeneration syndrome and one with progressive supranuclear palsy showed no [C-11]PIB but high [F-18]THK5317 retentions with a different regional distribution from that in Alzheimer's disease patients. Conclusions The tau-specific PET tracer [F-18]THK5317 images in vivo the expected regional distribution of tau pathology. This distribution contrasts with the different patterns of hypometabolism and amyloid-beta deposition.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Saint-Aubert, LaureKarolinska Institutet (författare)
  • Savitcheva, Irina (författare)
  • Jelic, VesnaKarolinska Institutet (författare)
  • Andersen, Pia (författare)
  • Jonasson, MyUppsala universitet,Radiologi(Swepub:uu)myajo391 (författare)
  • Eriksson, JonasUppsala universitet,Avdelningen för Molekylär Avbildning(Swepub:uu)joeri542 (författare)
  • Lubberink, MarkUppsala universitet,Radiologi(Swepub:uu)marklubb (författare)
  • Almkvist, OveStockholms universitet,Biologisk psykologi,Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden(Swepub:su)almkv (författare)
  • Wall, AndersUppsala universitet,Radiologi(Swepub:uu)andewall (författare)
  • Antoni, GunnarUppsala universitet,Avdelningen för Molekylär Avbildning(Swepub:uu)gunnarat (författare)
  • Nordberg, AgnetaKarolinska Institutet (författare)
  • Karolinska InstitutetRadiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC43:9, s. 1686-16991619-70701619-7089

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