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- Attoff, KristinaStockholm University,Stockholms universitet,Institutionen för neurokemi (author)
Acrylamide affects proliferation and differentiation of the neural progenitor cell line C17.2 and the neuroblastoma cell line SH-SY5Y
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-133367
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133367URI
- https://doi.org/10.1016/j.tiv.2016.05.014DOI
- https://lup.lub.lu.se/record/a6cbf7e5-1ab4-4365-afc9-f88d02ba68f5URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134004848URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Acrylamide is a well-known neurotoxic compound and people get exposed to the compound by food consumption and environmental pollutants. Since acrylamide crosses the placenta barrier, the fetus is also being exposed resulting in a risk for developmental neurotoxicity. In this study, the neural progenitor cell line C17.2 and the neuroblastoma cell line SH-SY5Y were used to study proliferation and differentiation as alerting indicators for developmental neurotoxicity. For both cell lines, acrylamide reduced the number of viable cells by reducing proliferation and inducing cell death in undifferentiated cells. Acrylamide concentrations starting at 10 fM attenuated the differentiation process in SH-SY5Y cells by sustaining cell proliferation and neurite outgrowth was reduced at concentrations from 10 pM. Acrylamide significantly reduced the number of neurons starting at 1 mu M and altered the ratio between the different phenotypes in differentiating C17.2 cell cultures. Ten micromolar of acrylamide also reduced the expression of the neuronal and astrocyte biomarkers. Although the neurotoxic concentrations in the femtomolar range seem to be specific for the SH-SY5Y cell line, the fact that micromolar concentrations of acrylamide seem to attenuate the differentiation process in both cell lines raises the interest to further investigations on the possible developmental neurotoxicity of acrylamide.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- Developmental neurotoxicity
- Acrylamide
- Neural progenitor cells
- SH-SY5Y
- C17.2
- Differentiation
- neurokemi med molekylär neurobiologi
- Neurochemistry with Molecular Neurobiology
- Acrylamide
- C17.2
- Developmental neurotoxicity
- Differentiation
- Neural progenitor cells
- SH-SY5Y
Added entries (persons, corporate bodies, meetings, titles ...)
- Kertika, DimitraStockholm University,Stockholms universitet,Institutionen för neurokemi (author)
- Lundqvist, JessicaStockholm University,Stockholms universitet,Institutionen för neurokemi(Swepub:su)jelu6259 (author)
- Oredsson, S.Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)zoof-sor (author)
- Forsby, AnnaKarolinska Institutet,Stockholm University,Stockholms universitet,Institutionen för neurokemi,Swedish Toxicology Science Center (Swetox)(Swepub:su)annaf (author)
- Stockholms universitetInstitutionen för neurokemi (creator_code:org_t)
Related titles
- In:Toxicology in Vitro: Elsevier BV35, s. 100-1110887-23331879-3177
Internet link
- https://doi.org/10.1016/j.tiv.2016.05.014Fulltext
- https://doi.org/10.1016/j.tiv.2016.05.014
- http://dx.doi.org/10.1016/j.tiv.2016.05.014FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133367
- https://doi.org/10.1016/j.tiv.2016.05.014
- https://lup.lub.lu.se/record/a6cbf7e5-1ab4-4365-afc9-f88d02ba68f5
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134004848
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