Search: id:"swepub:oai:DiVA.org:su-136238" >
Characterization of...
-
Wallin, CeciliaStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
(author)
Characterization of Mn(II) ion binding to the amyloid-beta peptide in Alzheimer's disease
- Article/chapterEnglish2016
Publisher, publication year, extent ...
-
Elsevier BV,2016
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-136238
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136238URI
-
https://doi.org/10.1016/j.jtemb.2016.03.009DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308063URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Growing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrations have been noted in Alzheimer's disease (AD) brains, yet the role of metals in AD pathogenesis remains unresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formation by amyloid-beta (A beta) peptides. Previous studies have shown that A beta displays specific binding to Cu(II) and Zn(II) ions, and such binding has been shown to modulate A beta aggregation. Here, we use nuclear magnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part of the A beta(1-40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism (CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecular modeling suggest that the weak binding of Mn(II) to A beta may not have a large effect on the peptide's aggregation into amyloid fibrils. However, identification of an additional metal ion displaying A beta binding reveals more complex AD metal chemistry than has been previously considered in the literature.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Kulkarni, Yashraj S.Uppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)yasku118
(author)
-
Abelein, AxelStockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc NVS, H1,Novum Pl 5, S-14157 Stockholm, Sweden.(Swepub:su)axab0026
(author)
-
Jarvet, JüriStockholms universitet,Institutionen för biokemi och biofysik,The National Institute of Chemical Physics and Biophysics, Estonia,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;NICPB, Akad Tee 23, EE-12618 Tallinn, Estonia.(Swepub:su)jyri
(author)
-
Liao, QinghuaForschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.
(author)
-
Strodel, BirgitForschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.;Univ Dusseldorf, Inst Theoret & Computat Chem, Univ Str 1, D-40225 Dusseldorf, Germany.
(author)
-
Olsson, LisaStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
(author)
-
Luo, JinghuiStockholms universitet,Institutionen för biokemi och biofysik,University of Oxford, UK,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England.
(author)
-
Abrahams, Jan PieterUniv Basel, Biozentrum, Klingelbergstr 70, CH-4056 Basel, Switzerland.;Paul Scherrer Inst, Dept Biol & Chem, Lab Biomol Res, OFLC 102, CH-5232 Villigen, Switzerland.
(author)
-
Sholts, Sabrina B.Stockholms universitet,Institutionen för biokemi och biofysik,National Museum of Natural History, USA,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Smithsonian Inst, Natl Museum Nat Hist, Dept Anthropol, 10th & Constitut Ave NW, Washington, DC 20013 USA.
(author)
-
Roos, Per M.Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Capio St Goran Hosp, Dept Clin Physiol, St Goransplan 1, S-11219 Stockholm, Sweden.
(author)
-
Kamerlin, Shina C. L.Uppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)lynka392
(author)
-
Gräslund, AstridStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.(Swepub:su)astrid
(author)
-
Wärmländer, Sebastian K. T. S.Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.(Swepub:su)seb
(author)
-
Stockholms universitetInstitutionen för biokemi och biofysik
(creator_code:org_t)
Related titles
-
In:Journal of Trace Elements in Medicine and Biology: Elsevier BV38, s. 183-1930946-672X1878-3252
Internet link
Find in a library
To the university's database
- By the author/editor
-
Wallin, Cecilia
-
Kulkarni, Yashra ...
-
Abelein, Axel
-
Jarvet, Jüri
-
Liao, Qinghua
-
Strodel, Birgit
-
show more...
-
Olsson, Lisa
-
Luo, Jinghui
-
Abrahams, Jan Pi ...
-
Sholts, Sabrina ...
-
Roos, Per M.
-
Kamerlin, Shina ...
-
Gräslund, Astrid
-
Wärmländer, Seba ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Journal of Trace ...
- By the university
-
Stockholm University
-
Uppsala University