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  • Wallin, CeciliaStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden. (author)

Characterization of Mn(II) ion binding to the amyloid-beta peptide in Alzheimer's disease

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-136238
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136238URI
  • https://doi.org/10.1016/j.jtemb.2016.03.009DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308063URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Growing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrations have been noted in Alzheimer's disease (AD) brains, yet the role of metals in AD pathogenesis remains unresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formation by amyloid-beta (A beta) peptides. Previous studies have shown that A beta displays specific binding to Cu(II) and Zn(II) ions, and such binding has been shown to modulate A beta aggregation. Here, we use nuclear magnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part of the A beta(1-40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism (CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecular modeling suggest that the weak binding of Mn(II) to A beta may not have a large effect on the peptide's aggregation into amyloid fibrils. However, identification of an additional metal ion displaying A beta binding reveals more complex AD metal chemistry than has been previously considered in the literature.

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  • Kulkarni, Yashraj S.Uppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)yasku118 (author)
  • Abelein, AxelStockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc NVS, H1,Novum Pl 5, S-14157 Stockholm, Sweden.(Swepub:su)axab0026 (author)
  • Jarvet, JüriStockholms universitet,Institutionen för biokemi och biofysik,The National Institute of Chemical Physics and Biophysics, Estonia,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;NICPB, Akad Tee 23, EE-12618 Tallinn, Estonia.(Swepub:su)jyri (author)
  • Liao, QinghuaForschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany. (author)
  • Strodel, BirgitForschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.;Univ Dusseldorf, Inst Theoret & Computat Chem, Univ Str 1, D-40225 Dusseldorf, Germany. (author)
  • Olsson, LisaStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden. (author)
  • Luo, JinghuiStockholms universitet,Institutionen för biokemi och biofysik,University of Oxford, UK,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England. (author)
  • Abrahams, Jan PieterUniv Basel, Biozentrum, Klingelbergstr 70, CH-4056 Basel, Switzerland.;Paul Scherrer Inst, Dept Biol & Chem, Lab Biomol Res, OFLC 102, CH-5232 Villigen, Switzerland. (author)
  • Sholts, Sabrina B.Stockholms universitet,Institutionen för biokemi och biofysik,National Museum of Natural History, USA,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Smithsonian Inst, Natl Museum Nat Hist, Dept Anthropol, 10th & Constitut Ave NW, Washington, DC 20013 USA. (author)
  • Roos, Per M.Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Capio St Goran Hosp, Dept Clin Physiol, St Goransplan 1, S-11219 Stockholm, Sweden. (author)
  • Kamerlin, Shina C. L.Uppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)lynka392 (author)
  • Gräslund, AstridStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.(Swepub:su)astrid (author)
  • Wärmländer, Sebastian K. T. S.Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.(Swepub:su)seb (author)
  • Stockholms universitetInstitutionen för biokemi och biofysik (creator_code:org_t)

Related titles

  • In:Journal of Trace Elements in Medicine and Biology: Elsevier BV38, s. 183-1930946-672X1878-3252

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