Search: WFRF:(Wärmländer Sebastian K T S)
> (2015-2019) >
Characterization of...
Characterization of Mn(II) ion binding to the amyloid-beta peptide in Alzheimer's disease
-
- Wallin, Cecilia (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
-
- Kulkarni, Yashraj S. (author)
- Uppsala universitet,Struktur- och molekylärbiologi
-
- Abelein, Axel (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc NVS, H1,Novum Pl 5, S-14157 Stockholm, Sweden.
-
show more...
-
- Jarvet, Jüri (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,The National Institute of Chemical Physics and Biophysics, Estonia,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;NICPB, Akad Tee 23, EE-12618 Tallinn, Estonia.
-
- Liao, Qinghua (author)
- Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.
-
- Strodel, Birgit (author)
- Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.;Univ Dusseldorf, Inst Theoret & Computat Chem, Univ Str 1, D-40225 Dusseldorf, Germany.
-
- Olsson, Lisa (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
-
- Luo, Jinghui (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,University of Oxford, UK,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England.
-
- Abrahams, Jan Pieter (author)
- Univ Basel, Biozentrum, Klingelbergstr 70, CH-4056 Basel, Switzerland.;Paul Scherrer Inst, Dept Biol & Chem, Lab Biomol Res, OFLC 102, CH-5232 Villigen, Switzerland.
-
- Sholts, Sabrina B. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,National Museum of Natural History, USA,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Smithsonian Inst, Natl Museum Nat Hist, Dept Anthropol, 10th & Constitut Ave NW, Washington, DC 20013 USA.
-
- Roos, Per M. (author)
- Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Capio St Goran Hosp, Dept Clin Physiol, St Goransplan 1, S-11219 Stockholm, Sweden.
-
- Kamerlin, Shina C. L. (author)
- Uppsala universitet,Struktur- och molekylärbiologi
-
- Gräslund, Astrid (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
-
- Wärmländer, Sebastian K. T. S. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
-
In: Journal of Trace Elements in Medicine and Biology. - : Elsevier BV. - 0946-672X .- 1878-3252. ; 38, s. 183-193
- Related links:
-
http://uu.diva-porta...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Growing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrations have been noted in Alzheimer's disease (AD) brains, yet the role of metals in AD pathogenesis remains unresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formation by amyloid-beta (A beta) peptides. Previous studies have shown that A beta displays specific binding to Cu(II) and Zn(II) ions, and such binding has been shown to modulate A beta aggregation. Here, we use nuclear magnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part of the A beta(1-40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism (CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecular modeling suggest that the weak binding of Mn(II) to A beta may not have a large effect on the peptide's aggregation into amyloid fibrils. However, identification of an additional metal ion displaying A beta binding reveals more complex AD metal chemistry than has been previously considered in the literature.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Manganese
- Neurodegeneration
- Metal-protein binding
- Spectroscopy
- Molecular dynamics
- Biophysics
- biofysik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wallin, Cecilia
-
Kulkarni, Yashra ...
-
Abelein, Axel
-
Jarvet, Jüri
-
Liao, Qinghua
-
Strodel, Birgit
-
show more...
-
Olsson, Lisa
-
Luo, Jinghui
-
Abrahams, Jan Pi ...
-
Sholts, Sabrina ...
-
Roos, Per M.
-
Kamerlin, Shina ...
-
Gräslund, Astrid
-
Wärmländer, Seba ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Journal of Trace ...
- By the university
-
Stockholm University
-
Uppsala University