Cardioprotection and lifespan extension by the natural polyamine spermidine

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Eisenberg, Tobias (author)

Cardioprotection and lifespan extension by the natural polyamine spermidine

Article/chapterEnglish2016

Publisher, publication year, extent ...

2016-11-14
Springer Science and Business Media LLC,2016
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:su-137601
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-137601URI
https://doi.org/10.1038/nm.4222DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134723225URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.

Subject headings and genre

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Abdellatif, Mahmoud (author)
Schroeder, Sabrina (author)
Primessnig, Uwe (author)
Stekovic, Slaven (author)
Pendl, Tobias (author)
Harger, Alexandra (author)
Schipke, Julia (author)
Zimmermann, Andreas (author)
Schmidt, Albrecht (author)
Tong, Mingming (author)
Ruckenstuhl, Christoph (author)
Dammbrueck, Christopher (author)
Gross, Angelina S. (author)
Herbst, Viktoria (author)
Magnes, Christoph (author)
Trausinger, Gert (author)
Narath, Sophie (author)
Meinitzer, Andreas (author)
Hu, Zehan (author)
Kirsch, Alexander (author)
Eller, Kathrin (author)
Carmona-Gutierrez, Didac (author)
Büttner, SabrinaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria(Swepub:su)sab (author)
Pietrocola, Federico (author)
Knittelfelder, Oskar (author)
Schrepfer, Emilie (author)
Rockenfeller, Patrick (author)
Simonini, Corinna (author)
Rahn, Alexandros (author)
Horsch, Marion (author)
Moreth, Kristin (author)
Beckers, Johannes (author)
Fuchs, Helmut (author)
Gailus-Durner, Valerie (author)
Neff, Frauke (author)
Janik, Dirk (author)
Rathkolb, Birgit (author)
Rozman, Jan (author)
de Angelis, Martin Hrabe (author)
Moustafa, Tarek (author)
Haemmerle, Guenter (author)
Mayr, Manuel (author)
Willeit, Peter (author)
von Frieling-Salewsky, Marion (author)
Pieske, Burkert (author)
Scorrano, Luca (author)
Pieber, Thomas (author)
Pechlaner, Raimund (author)
Willeit, Johann (author)
Sigrist, Stephan J. (author)
Linke, Wolfgang A. (author)
Muehlfeld, Christian (author)
Sadoshima, Junichi (author)
Dengjel, Joern (author)
Kiechl, Stefan (author)
Kroemer, Guido (author)
Sedej, Simon (author)
Madeo, Frank (author)
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

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In:Nature Medicine: Springer Science and Business Media LLC22:12, s. 1428-14381078-89561546-170X

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By the author/editor: Eisenberg, Tobia ...; Abdellatif, Mahm ...; Schroeder, Sabri ...; Primessnig, Uwe; Stekovic, Slaven; Pendl, Tobias; show more...; Harger, Alexandr ...; Schipke, Julia; Zimmermann, Andr ...; Schmidt, Albrech ...; Tong, Mingming; Ruckenstuhl, Chr ...; Dammbrueck, Chri ...; Gross, Angelina ...; Herbst, Viktoria; Magnes, Christop ...; Trausinger, Gert; Narath, Sophie; Meinitzer, Andre ...; Hu, Zehan; Kirsch, Alexande ...; Eller, Kathrin; Carmona-Gutierre ...; Büttner, Sabrina; Pietrocola, Fede ...; Knittelfelder, O ...; Schrepfer, Emili ...; Rockenfeller, Pa ...; Simonini, Corinn ...; Rahn, Alexandros; Horsch, Marion; Moreth, Kristin; Beckers, Johanne ...; Fuchs, Helmut; Gailus-Durner, V ...; Neff, Frauke; Janik, Dirk; Rathkolb, Birgit; Rozman, Jan; de Angelis, Mart ...; Moustafa, Tarek; Haemmerle, Guent ...; Mayr, Manuel; Willeit, Peter; von Frieling-Sal ...; Pieske, Burkert; Scorrano, Luca; Pieber, Thomas; Pechlaner, Raimu ...; Willeit, Johann; Sigrist, Stephan ...; Linke, Wolfgang ...; Muehlfeld, Chris ...; Sadoshima, Junic ...; Dengjel, Joern; Kiechl, Stefan; Kroemer, Guido; Sedej, Simon; Madeo, Frank; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Nature Medicine

By the university: Stockholm University; Karolinska Institutet

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