id:"swepub:oai:DiVA.org:su-143137"
Search: id:"swepub:oai:DiVA.org:su-143137" > β3-Adrenergically i...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Olsen, Jessica M.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska University Hospital Solna, Sweden (author)
β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity : Mediation through the mTOR pathway
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Elsevier BV,2017
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-143137
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143137URI
- https://doi.org/10.1016/j.molmet.2017.02.006DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:136230430URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- ObjectiveToday, the presence and activity of brown adipose tissue (BAT) in adult humans is generally equated with the induced accumulation of [2-18F]2-fluoro-2-deoxy-d-glucose([18F]FDG) in adipose tissues, as investigated by positron emission tomography (PET) scanning. In reality, PET-FDG is currently the only method available for in vivoquantification of BAT activity in adult humans. The underlying assumption is that the glucose uptake reflects the thermogenic activity of the tissue.MethodsTo examine this basic assumption, we here followed [18F]FDG uptake by PET and by tissue [3H]-2-deoxy-d-glucose uptake in wildtype and UCP1(−/−) mice, i.e. in mice that do or do not possess the unique thermogenic and calorie-consuming ability of BAT.ResultsUnexpectedly, we found that β3-adrenergically induced (by CL-316,243) glucose uptake was UCP1-independent. Thus, whereas PET-FDG scans adequately reflect glucose uptake, this acute glucose uptake is not secondary to thermogenesis but is governed by an independent cellular signalling, here demonstrated to be mediated via the previously described KU-0063794-sensitive mTOR pathway.ConclusionsThus, PET-FDG scans do not exclusively reveal active BAT deposits but rather any tissue possessing an adrenergically-mediated glucose uptake pathway. In contrast, we found that the marked glucose uptake-ameliorating effect of prolonged β3-adrenergictreatment was UCP1 dependent. Thus, therapeutically, UCP1 activity is required for any anti-diabetic effect of BAT activation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- Brown adipose tissue
- Uncoupling protein 1
- Glucose uptake
- Adrenergic signaling
- Positron emission tomography
- fysiologi
- Physiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Csikasz, Robert I.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska University Hospital Solna, Sweden(Swepub:su)rocs5038 (author)
- Dehvari, NodiStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)node4175 (author)
- Lu, Li (author)
- Sandström, AnnaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)ansa2665 (author)
- Öberg, Anette I.Karolinska Institutet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut (author)
- Nedergaard, JanStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)neder (author)
- Stone-Elander, SharonKarolinska Institutet (author)
- Bengtsson, ToreStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)tbeng (author)
- Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)
Related titles
- In:Molecular Metabolism: Elsevier BV6:6, s. 611-6192212-8778
Internet link
Find in a library
- Molecular Metabolism (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Olsen, Jessica M ...
- Csikasz, Robert ...
- Dehvari, Nodi
- Lu, Li
- Sandström, Anna
- Öberg, Anette I.
- show more...
- Nedergaard, Jan
- Stone-Elander, S ...
- Bengtsson, Tore
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Physiology
- Articles in the publication
- Molecular Metabo ...
- By the university
- Stockholm University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
