Allopregnanolone impairs episodic memory in healthy women

Kask, KristiinaUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson (author)

Allopregnanolone is an endogenous neuroactive steroid that, through its binding to the γ-aminobutyric acid (GABA) A receptor, has GABA-active properties. Animal studies indicate that allopregnanolone administration results in diminished learning and memory impairment. The aim of the current study was to investigate the effect of intravenously administered allopregnanolone on episodic memory, semantic memory, and working memory in healthy women. Twenty-eight healthy women were included in the study. The participants were scheduled for the memory tests twice in the follicular phase. During the test sessions, an intravenous allopregnanolone and placebo infusion were administered in a double-blinded, randomized order at intervals of 48 h. Before and 10 min after the allopregnanolone/placebo injections, memory tasks were performed. The study demonstrated that allopregnanolone impaired episodic memory in healthy women. There was a significant difference between pre- and postallopregnanolone injection episodic memory scores (p < 0.05), whereas there was no change in episodic memory performance following the placebo injections. There was also a significant difference between allopregnanolone and placebo postinjection episodic memory scores (p < 0.05). There were no effects of allopregnanolone on the semantic memory task or working memory task. Intravenous allopregnanolone impairs episodic memory in healthy women, but there is a high degree of individual variability.

Bäckström, TorbjörnUmeå universitet,Obstetrik och gynekologi,Department of Clinical Science, Obstetrics and Gynecology, Umeå University, Umeå, Sweden(Swepub:umu)toba0001 (author)
Nilsson, Lars-GöranStockholms universitet,Psykologiska institutionen,Department of Psychology, Stockholm University, Stockholm, Sweden(Swepub:su)lgn (author)
Sundström Poromaa, IngerUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)inspo702 (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

In:Psychopharmacology: Springer Science and Business Media LLC199:2, s. 161-1680033-31581432-2072

By the author/editor: Kask, Kristiina; Bäckström, Torbj ...; Nilsson, Lars-Gö ...; Sundström Poroma ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

By the university: Stockholm University; Umeå University; Uppsala University

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.