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- Bergqvist, CeciliaStockholms universitet,Institutionen för neurokemi (author)
An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Elsevier BV,2017
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:su-147935
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147935URI
- https://doi.org/10.1016/j.scr.2017.06.008DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- The ability of iPSCs (induced pluripotent stem cells) to generate any cell type in the body makes them valuable tools for cell replacement therapies. However, differentiation of iPSCs can be demanding, slowand variable. During differentiation chromatin is re-organized and silent dense heterochromatin becomes tethered to the nuclear periphery by processes involving the nuclear lamina and proteins of the INM(inner nuclearmembrane). The INM protein, Samp1 (Spindle AssociatedMembrane Protein 1) interacts with Lamin A/C and the INMprotein Emerin, which has a chromatin binding LEM(Lap2-Emerin-Man1)-domain. In this paperweinvestigate if Samp1 can play a role in the differentiation of iPSCs. Samp1 levels increased as differentiating iPSCs started to express Lamin A/C. Interestingly, even under pluripotent culturing conditions, ectopic expression of Samp1 induced a rapid differentiation of iPSCs, ofwhich some expressed the neuronal marker beta III-tubulin already after 6 days. This suggests that Samp1 is involved in early differentiation of iPSCs and could potentially be explored as a tool to promote progression of the differentiation process.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Medicinteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Medical Engineering hsv//eng
- TEKNIK OCH TEKNOLOGIER Miljöbioteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Environmental Biotechnology hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- Nuclear membrane
- Nuclear envelope
- Induced pluripotent stem cells
- Neuronal differentiation
- Regenerative medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Jafferali, Mohammed HakimStockholms universitet,Institutionen för neurokemi(Swepub:su)moja2628 (author)
- Gudise, SanthoshStockholms universitet,Institutionen för neurokemi (author)
- Markus, RobertStockholms universitet,Institutionen för neurokemi (author)
- Hallberg, EinarStockholms universitet,Institutionen för neurokemi(Swepub:su)eihal (author)
- Stockholms universitetInstitutionen för neurokemi (creator_code:org_t)
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- In:Stem Cell Research: Elsevier BV23, s. 33-381873-50611876-7753
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