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An Expanded Genome-...
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
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- Scott, Robert A. (author)
- University of Cambridge,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Scott, Laura J. (author)
- University of Michigan,Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Maegi, Reedik (author)
- University of Tartu,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Marullo, Letizia (author)
- University of Ferrara,Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
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- Gaulton, Kyle J. (author)
- University of Oxford,Stanford University,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Stanford Univ, Dept Genet, Stanford, CA USA.
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- Kaakinen, Marika (author)
- Imperial College London,Imperial Coll London, Dept Genom Common Dis, London, England.
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- Pervjakova, Natalia (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Pers, Tune H. (author)
- Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.
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- Johnson, Andrew D. (author)
- Natl Heart Lung & Blood Inst, Div Intramural Res, Framingham Heart Study Populat Sci Branch, Framingham, MA USA.
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- Eicher, John D. (author)
- Natl Heart Lung & Blood Inst, Div Intramural Res, Framingham Heart Study Populat Sci Branch, Framingham, MA USA.
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- Jackson, Anne U. (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Ferreira, Teresa (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Lee, Yeji (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Ma, Clement (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Steinthorsdottir, Valgerdur (author)
- Amgen Inc, DECODE genet, Reykjavik, Iceland.
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- Thorleifsson, Gudmar (author)
- Amgen Inc, DECODE genet, Reykjavik, Iceland.
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- Qi, Lu (author)
- Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.
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- Van Zuydam, Natalie R. (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Mahajan, Anubha (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Chen, Han (author)
- Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Human Genet Ctr & Dept Epidemiol, Human Genet Environm Sci, Houston, TX USA.;Univ Texas Hlth Sci Ctr, Sch Biomed Informat, Sch Biomed Informat, Ctr Precis Hlth, Houston, TX USA.
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Diabetes - Cardiovascular Disease,Lund University Research Groups,Cardiovascular Research - Hypertension,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.
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- Voight, Ben F. (author)
- Univ Penn sylvania, Perelman Sch Med, Dept Pharm, Philadelphia, PA USA.;Univ Pennsylvania, Perelman Sch Med, Dept Genet, Philadelphia, PA USA.;Univ Pennsylvania, Perelman Sch Medi cine, Inst Translat Med & Therapeut, Philadelphia, PA USA.
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- Grallert, Harald (author)
- Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.
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- Mueller-Nurasyid, Martina (author)
- German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Univ Hosp Grosshadern, Ludwig Maximilians Univ, Dep Med I, Munich, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat, Genet Epidemiol, Biometry & Epidemiol, Munich, Germany.;Munich Heart Alliance, German Ctr Cardiovascular Dis, Munich, Germany.
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- Ried, Janina S. (author)
- Karolinska Institutet,German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
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- Rayner, Nigel W. (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Wellcome Trust Sanger Inst, Hinxton, England.
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- Robertson, Neil (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.
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- Karssen, Lennart C. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Polyomica S Hertogenbosch, Amsterdam, Netherlands.
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- Van Leeuwen, Elisabeth M. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Willems, Sara M. (author)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Fuchsberger, Christian (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Kwan, Phoenix (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Teslovich, Tanya M. (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Chanda, Pritam (author)
- Johns Hopkins Univ Sch Med, High Throughput Biol Ctr, Baltimore, MD USA.
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- Li, Man (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Lu, Yingchang (author)
- Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.;Icahn Sch Med, Genet Obes & Related Metab Traits Program, Mt Sinai, New York, NY USA.
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- Dina, Christian (author)
- Univ Nantes, CNRS, Inst Thorax, Ctr Hosp Univ Nantes, Nantes, France.
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- Thuillier, Dorothee (author)
- Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.
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- Yengo, Loic (author)
- Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.
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- Jiang, Longda (author)
- Imperial Coll London, Dept Genom Common Dis, London, England.
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- Sparso, Thomas (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
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- Kestler, Hans A. (author)
- Fritz Lipmann Inst, Leibniz Inst Aging, Jena, Germany.;Univ Ulm, Inst Med Syst Biol, Ulm, Germany.
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- Chheda, Himanshu (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
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- Eisele, Lewin (author)
- Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Frånberg, Mattias (author)
- Stockholms universitet,Numerisk analys och datalogi (NADA),Science for Life Laboratory (SciLifeLab),Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden.
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- Strawbridge, Rona J. (author)
- Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.
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- Benediktsson, Rafn (author)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Hreidarsson, Astradur B. (author)
- Landspitali Univ Hosp, Reykjavik, Iceland.,INSERM, CESP, UMR 1018, Villejuif, France.;Univ Paris Sud, UMR 1018, Villejuif, France.
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- Kong, Augustine (author)
- Amgen Inc, DECODE genet, Reykjavik, Iceland.
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- Sigurdsson, Gunnar (author)
- Landspitali Univ Hosp, Reykjavik, Iceland.;Iceland Heart Assoc, Kopavogur, Iceland.
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- Kerrison, Nicola D. (author)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Luan, Jian'an (author)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Liang, Liming (author)
- Karolinska Institutet,Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Biostatist, Boston, MA USA.,Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.,Karolinska Inst tutet, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.,Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
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- Meitinger, Thomas (author)
- Munich Heart Alliance, German Ctr Cardiovascular Dis, Munich, Germany.;Fritz Lipmann Inst, Leibniz Inst Aging, Jena, Germany.;Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany. Tech Univ Munich, Inst Human Genet, Munich, Germany.
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- Roden, Michael (author)
- German Ctr Diabet Res, Neuherberg, Germany.;Heinrich Heine Univ, Fac Med, Dept Endocrinol & Diabet, Dusseldorf, Germany.;Heinrich Heine Univ Dusseldorf, Leibniz Inst Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
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- Thorand, Barbara (author)
- German Ctr Diabet Res, Neuherberg, Germany.
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- Esko, Tonu (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Boston Childrens Hosp, Divis Genet & Endocrinol, Boston, MA USA.;Natl Heart Lung & Blood Inst, Framingham Heart Study, Framingham, MA USA.
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- Mihailov, Evelin (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Fox, Caroline (author)
- Harvard Med Sch, Divis Endocrinol, Diabet & Hypertens, Brigham & Womens Hosp, Boston, MA USA.
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- Liu, Ching-Ti (author)
- Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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- Rybin, Denis (author)
- Boston Univ Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA.
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- Isomaa, Bo (author)
- Folkhalsan Res Ctr, Helsinki, Finland.;Dept Social Serv & Hlth Care, Pietarsaari, Finland.
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.
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- Tuomi, Tiinamaija (author)
- Folkhalsan Res Ctr, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Dept Med, Helsinki, Finland.,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.,Univ Exeter Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England.,Univ Med Ctr Utrecht, Utrecht, Netherlands.
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- Couper, David J. (author)
- Univ N Carolina, Dept Biostatist, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.
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- Pankow, James S. (author)
- Univ Minnesota, Divis Epidemiol Community Hlth, Minneapolis, MN USA.
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- Grarup, Niels (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
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Have, Christian T. (author)
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- Jorgensen, Marit E. (author)
- Steno Diabet Ctr, Gentofte, Denmark.,Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.
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- Jorgensen, Torben (author)
- Capital Region Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark.
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- Linneberg, Allan (author)
- Capital Region Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Copenhagen Univ Hosp, Rigshospitalet, Copenhagen, Denmark. Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-1168 Copenhagen, Denmark.
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- Cornelis, Marilyn C. (author)
- NW Univ Feinberg Sch Med, Dept Prevent Med, Chicago, IL USA.,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Healthy Ageing & Ctr Med Syst Biol, Netherlands Consortium, Netherlands Genom Initiat, Rotterdam, Netherlands.
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- Van Dam, Rob M. (author)
- Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
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- Hunter, David J. (author)
- Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
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- Kraft, Peter (author)
- Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Biostatist, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
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- Sun, Qi (author)
- Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.
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- Edkins, Sarah (author)
- Wellcome Trust Sanger Inst, Hinxton, England.
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- Owen, Katharine R. (author)
- Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Churchill Hosp, Oxford, England.
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Perry, John R. B. (author)
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- Wood, Andrew R. (author)
- Univ Exeter Med Sch, Univ Exeter, Genet Complex Traits, Exeter, Devon, England.
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- Zeggini, Eleftheria (author)
- Wellcome Trust Sanger Inst, Hinxton, England.
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- Tajes-Fernandes, Juan (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Abecasis, Goncalo R. (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Chines, Peter S. (author)
- Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.
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- Stringham, Heather M. (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
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- Koistinen, Heikki A. (author)
- Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Cent Hosp, Dept Med & Abdominal Ctr, Endocrinol, Helsinki, Finland.;Biomedicum Helsinki 2U, Minerva Fdn Inst Med Res, Helsinki, Finland.
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- Kinnunen, Leena (author)
- Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Cent Hosp, Dept Med & Abdominal Ctr, Endocrinol, Helsinki, Finland.;Biomedicum Helsinki 2U, Minerva Fdn Inst Med Res, Helsinki, Finland.
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- Sennblad, Bengt (author)
- Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.
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- Muehleisen, Thomas W. (author)
- Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life Brain Ctr, Bonn, Germany.
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- Noethen, Markus M. (author)
- Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life Brain Ctr, Bonn, Germany.
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- Pechlivanis, Sonali (author)
- Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.
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- Baldassarre, Damiano (author)
- Ist Ricovero Cura Carattere Sci, Ctr Cardiologico Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol Biomol, Milan, Italy.
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- Gertow, Karl (author)
- Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.
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- Humphries, Steve E. (author)
- UCL, Inst Cardiovascular Sci, BHF Labs, Cardiovascular Genet, London, England.
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- Tremoli, Elena (author)
- Ist Ricovero Cura Carattere Sci, Ctr Cardiologico Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol Biomol, Milan, Italy.
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- Klopp, Norman (author)
- Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
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- Meyer, Julia (author)
- German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Dept Stat, Oxford, England.
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- Steinbach, Gerald (author)
- Univ Ulm, Dept Clin Chem & Cent Lab, Ulm, Germany.
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- Wennauer, Roman (author)
- Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
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- Eriksson, Johan G. (author)
- Folkhalsan Res Ctr, Helsinki, Finland.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.;Helsinki Univ Cent Hosp, Unit Gen Practice, Helsinki, Finland.
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- Mannisto, Satu (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
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- Peltonen, Leena (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Broad Inst & Harvard, Cambridge, MA USA.
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- Tikkanen, Emmi (author)
- Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland.
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- Charpentier, Guillaume (author)
- Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Corbeil Essonnes, France.
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Eury, Elodie (author)
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- Lobbens, Stephane (author)
- Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.
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- Gigante, Bruna (author)
- Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.
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- Leander, Karin (author)
- Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.
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- McLeod, Olga (author)
- Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.
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- Bottinger, Erwin P. (author)
- Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.
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- Gottesman, Omri (author)
- Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.
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- Ruderfer, Douglas (author)
- Icahn Sch Med, Dept Psychiat, Divis Psychiat Genom, Mt Sinai, New York, NY USA.
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- Blueher, Matthias (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.
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- Kovacs, Peter (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.
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- Tonjes, Anke (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.
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- Maruthur, Nisa M. (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Med, Dept Med, Divis Gen Internal Med, Baltimore, MD USA.;Johns Hopkins Univ, Welch Ctr Prevent, Epidemiol & Clin Res, Baltimore, MD USA.
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- Scapoli, Chiara (author)
- Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
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- Erbel, Raimund (author)
- Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.
-
- Joeckel, Karl-Heinz (author)
- Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.
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- Moebus, Susanne (author)
- Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.
-
- De Faire, Ulf (author)
- Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.
-
- Hamsten, Anders (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.
-
- Stumvoll, Michael (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.
-
- Deloukas, Panagiotis (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England.
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Donnelly, Peter J. (author)
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- Frayling, Timothy M. (author)
- Univ Exeter Med Sch, Univ Exeter, Genet Complex Traits, Exeter, Devon, England.
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Hattersley, Andrew T. (author)
-
- Ripatti, Samuli (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.
-
- Salomaa, Veikko (author)
- Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Boehm, Bernhard O. (author)
- Univ Med Ctr Ulm, Dept Internal Med, Divis Endocrinol & Diabet, Ulm, Germany.;Nanyang Technol Univ, Imperial Coll London, Lee Kong Chian Sch Med, Singapore, Singapore.
-
- Bergman, Richard N. (author)
- Cedars Sinai Med Ctr, Diabetes & Obes Res Inst, Los Angeles, CA USA.
-
- Collins, Francis S. (author)
- Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.
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Mohlke, Karen L. (author)
-
- Tuomilehto, Jaakko (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Dasman Diabet Inst, Dasman, Kuwait.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabetes Res Grp, Jeddah, Saudi Arabia.
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- Hansen, Torben (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Univ So Denmark, Fac Hlth Sci, Odense, Denmark.
-
- Pedersen, Oluf (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
-
- Barroso, Ines (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Addenbrookes Hosp Cambridge, Wellcome Trust MRC Inst Metab Sci, Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.;Univ Cambridge Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.
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Lannfelt, Lars (author)
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Lind, Lars (author)
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- Lindgren, Cecilia M. (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst & Harvard, Cambridge, MA USA.
-
- Cauchi, Stephane (author)
- Lille Inst Biol, European Genom Inst Diabet, Lille, France.
-
- Froguel, Philippe (author)
- Imperial Coll London, Dept Genom Common Dis, London, England.;Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.
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- Loos, Ruth J. F. (author)
- Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.;Icahn Sch Med, Genet Obes & Related Metab Traits Program, Mt Sinai, New York, NY USA.;Mindich Child Hlth & Dev Inst, Icahn Sch Med, Mt Sinai, New York, NY USA.
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- Balkau, Beverley (author)
- Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Amgen Inc, DECODE genet, Reykjavik, Iceland.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Gen Med Divis, Boston, MA USA.,Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.
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- Boeing, Heiner (author)
- German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany.
-
- Franks, Paul W. (author)
- Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Lund Univ, Malmo, Sweden.;Umea Univ, Umea, Sweden.
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- Gurrea, Aurelio Barricarte (author)
- Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res, Pamplona, Spain.;CIBER Epidemiol & Publ Hlth, Madrid, Spain.
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- Palli, Domenico (author)
- Canc Res & Prevent Inst, Florence, Italy.
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Van der Schouw, Yvonne T. (author)
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- Altshuler, David (author)
- Broad Inst & Harvard, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.;Harvard Med Sch, Dept Mol Biol, Boston, MA USA.;Massachusetts Gen Hosp, Diabet Unit, Boston, MA USA.
-
- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
-
- Langenberg, Claudia (author)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
-
- Wareham, Nicholas J. (author)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
-
- Sijbrands, Eric (author)
- Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
-
Van Duijn, Cornelia M. (author)
-
- Florez, Jose C. (author)
- Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Diabet Unit, Boston, MA USA.
-
Meigs, James B. (author)
-
- Boerwinkle, Eric (author)
- Univ Texas Hlth Sci Ctr, Human Genet Ctr, Houston, TX USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX USA.
-
- Gieger, Christian (author)
- Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol II, Helmholtz Zentrum Munchen, Neuherberg, Germany.
-
- Strauch, Konstantin (author)
- German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat, Genet Epidemiol, Biometry & Epidemiol, Munich, Germany.
-
- Metspalu, Andres (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia.
-
- Morris, Andrew D. (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
-
- Palmer, Colin N. A. (author)
- Univ Dundee, Biomed Res Inst, Ninewells Hosp, Cardiovascular & Diabet Med, Dundee, Scotland.
-
Hu, Frank B. (author)
-
- Thorsteinsdottir, Unnur (author)
- Amgen Inc, DECODE genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
-
- Stefansson, Kari (author)
- Amgen Inc, DECODE genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
-
- Dupuis, Josee (author)
- Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA USA.
-
- Morris, Andrew P. (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England.
-
- Boehnke, Michael (author)
- Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.
-
- McCarthy, Mark I. (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Churchill Hosp, Oxford, England.
-
- Prokopenko, Inga (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Imperial Coll London, Dept Genom Common Dis, London, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.
-
show less...
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University of Cambridge Univ Cambridge, MRC Epidemiol Unit, Cambridge, England (creator_code:org_t)
- 2017-05-31
- 2017
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 66:11, s. 2888-2902
- Related links:
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https://diabetes.dia...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 x 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Datavetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Computer Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Caucasian
- gene expression regulation
- genetic variation
- genetics
- genome-wide association study
- human
- non insulin dependent diabetes mellitus
- physiology
- Diabetes Mellitus, Type 2
- European Continental Ancestry Group
- Gene Expression Regulation
- Genetic Variation
- Genome-Wide Association Study
- Humans
- ANDIS
- diabetes
- diabetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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Scott, Robert A.
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Scott, Laura J.
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Maegi, Reedik
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Marullo, Letizia
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Lannfelt, Lars
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Chines, Peter S.
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Stringham, Heath ...
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Sennblad, Bengt
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Altshuler, David
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Wareham, Nichola ...
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Sijbrands, Eric
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Van Duijn, Corne ...
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Florez, Jose C.
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Meigs, James B.
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Boerwinkle, Eric
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Strauch, Konstan ...
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Metspalu, Andres
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Morris, Andrew D ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Diabetes
- By the university
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Stockholm University
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University