Search: WFRF:(Osman Omneya Ahmed) >
Early-Life Human Mi...
-
Petursdottir, Dagbjort H.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2017-12-01
-
Frontiers Media SA,2017
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-150873
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-150873URI
-
https://doi.org/10.3389/fimmu.2017.01699DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137164703URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343555URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The intestinal microbiota influences immune maturation during childhood, and is implicated in early-life allergy development. However, to directly study intestinal microbes and gut immune responses in infants is difficult. To investigate how different types of early-life gut microbiota affect immune development, we collected fecal samples from children with different allergic heredity (AH) and inoculated germ-free mice. Immune responses and microbiota composition were evaluated in the offspring of these mice. Microbial composition in the small intestine, the cecum and the colon were determined by 16S rRNA sequencing. The intestinal microbiota differed markedly between the groups of mice, but only exposure to microbiota associated with AH and known future allergy in children resulted in a T helper 17 (Th17)-signature, both systemically and in the gut mucosa in the mouse offspring. These Th17 responses could be signs of a particular microbiota and a shift in immune development, ultimately resulting in an increased risk of allergy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Nordlander, SofiaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)sofno
(author)
-
Qazi, Khaleda RahmanStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)qazi
(author)
-
Carvalho-Queiroz, ClaudiaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)clqu0874
(author)
-
Osman, Omneya AhmedStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)oahme
(author)
-
Hell, EvaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)evhel
(author)
-
Björkander, SophiaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)sobj9073
(author)
-
Haileselassie, YenenehStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)yhail
(author)
-
Navis, MaritStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
-
Kokkinou, EfthymiaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
-
Lio, Ivan Zong LongStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
-
Hennemann, JuliaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
-
Brodin, BjörnStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
(author)
-
Huseby, Douglas L.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)douhu661
(author)
-
Nilsson, CarolineKarolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Sachs Childrens Hosp, Stockholm, Sweden.
(author)
-
Hughes, Diarmaid,1956-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)diarhugh
(author)
-
Udekwu, Klas I.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)kudek
(author)
-
Sverremark-Ekström, EvaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.(Swepub:su)esver
(author)
-
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
Related titles
-
In:Frontiers in Immunology: Frontiers Media SA81664-3224
Internet link
Find in a library
To the university's database
- By the author/editor
-
Petursdottir, Da ...
-
Nordlander, Sofi ...
-
Qazi, Khaleda Ra ...
-
Carvalho-Queiroz ...
-
Osman, Omneya Ah ...
-
Hell, Eva
-
show more...
-
Björkander, Soph ...
-
Haileselassie, Y ...
-
Navis, Marit
-
Kokkinou, Efthym ...
-
Lio, Ivan Zong L ...
-
Hennemann, Julia
-
Brodin, Björn
-
Huseby, Douglas ...
-
Nilsson, Carolin ...
-
Hughes, Diarmaid ...
-
Udekwu, Klas I.
-
Sverremark-Ekstr ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Frontiers in Imm ...
- By the university
-
Stockholm University
-
Karolinska Institutet
-
Uppsala University