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  • Zhang, Sicai (author)

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier BV,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-153739
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-153739URI
  • https://doi.org/10.1016/j.chom.2017.12.018DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Botulinumneurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative genomic analysis determines that the E. faecium strain carrying BoNT/En is a commensal type and that the BoNT/En gene is located within a typical BoNT gene cluster on a 206 kb putatively conjugative plasmid. Although the host species targeted by BoNT/En remains to be determined, these findings establish an extended member of BoNTs and demonstrate the capability of E. faecium, a commensal organism ubiquitous in humans and animals and a leading cause of hospital-acquired multi-drug-resistant (MDR) infections, to horizontally acquire, and possibly disseminate, a unique BoNT gene cluster.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lebreton, Francois (author)
  • Mansfield, Michael J. (author)
  • Miyashita, Shin-Ichiro (author)
  • Zhang, Jie (author)
  • Schwartzman, Julia A. (author)
  • Tao, Liang (author)
  • Masuyer, GeoffreyStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)gmasu (author)
  • Martínez-Carranza, MarkelStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)mama6974 (author)
  • Stenmark, PålStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)stenm (author)
  • Gilmore, Michael S. (author)
  • Doxey, Andrew C. (author)
  • Dong, Min (author)
  • Stockholms universitetInstitutionen för biokemi och biofysik (creator_code:org_t)

Related titles

  • In:Cell Host and Microbe: Elsevier BV23:2, s. 169-1761931-31281934-6069

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