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Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
- Article/chapterEnglish2018
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Elsevier BV,2018
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LIBRIS-ID:oai:DiVA.org:su-153739
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-153739URI
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https://doi.org/10.1016/j.chom.2017.12.018DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Botulinumneurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative genomic analysis determines that the E. faecium strain carrying BoNT/En is a commensal type and that the BoNT/En gene is located within a typical BoNT gene cluster on a 206 kb putatively conjugative plasmid. Although the host species targeted by BoNT/En remains to be determined, these findings establish an extended member of BoNTs and demonstrate the capability of E. faecium, a commensal organism ubiquitous in humans and animals and a leading cause of hospital-acquired multi-drug-resistant (MDR) infections, to horizontally acquire, and possibly disseminate, a unique BoNT gene cluster.
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Lebreton, Francois
(author)
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Mansfield, Michael J.
(author)
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Miyashita, Shin-Ichiro
(author)
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Zhang, Jie
(author)
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Schwartzman, Julia A.
(author)
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Tao, Liang
(author)
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Masuyer, GeoffreyStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)gmasu
(author)
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Martínez-Carranza, MarkelStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)mama6974
(author)
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Stenmark, PålStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)stenm
(author)
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Gilmore, Michael S.
(author)
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Doxey, Andrew C.
(author)
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Dong, Min
(author)
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Stockholms universitetInstitutionen för biokemi och biofysik
(creator_code:org_t)
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In:Cell Host and Microbe: Elsevier BV23:2, s. 169-1761931-31281934-6069
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Zhang, Sicai
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Lebreton, Franco ...
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Mansfield, Micha ...
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Miyashita, Shin- ...
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Zhang, Jie
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Schwartzman, Jul ...
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Tao, Liang
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Masuyer, Geoffre ...
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Stenmark, Pål
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Gilmore, Michael ...
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Doxey, Andrew C.
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Dong, Min
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Cell Host and Mi ...
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Stockholm University