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  • Miguel, SophieMars Wrigley, 1132 W Blackhawk St, Chicago, IL 60642 USA. (författare)

Poor cognitive ageing : Vulnerabilities, mechanisms and the impact of nutritional interventions

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-154799
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-154799URI
  • https://doi.org/10.1016/j.arr.2017.12.004DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355830URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137809154URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop 'Nutrition for the Ageing Brain: Functional Aspects and Mechanisms' in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Champ, ClaireUniv Leeds, Sch Psychol, Human Appetite Res Unit, Leeds LS2 9JT, W Yorkshire, England. (författare)
  • Day, JonCerebrus Associates Ltd, White House,2 Meadrow, Godalming GU7 3HN, Surrey, England. (författare)
  • Aarts, EstherRadboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Kapittelweg 29, NL-6525 EN Nijmegen, Netherlands. (författare)
  • Bahr, Ben A.Univ N Carolina, Biotechnol Res & Training Ctr, Pembroke, WA USA. (författare)
  • Bakker, MartijntjeNetherlands Org Hlth Res & Dev, Laan Nieuw Oost Indie 334, NL-2593 CE The Hague, Netherlands. (författare)
  • Banati, DianaEurope ILSI Europe, Int Life Sci Inst, E Mounier 83,Box 6, B-1200 Brussels, Belgium. (författare)
  • Calabrese, VittorioUniv Catania, Dept Biomed & Biotechnol Sci, Biol Tower Via Santa Sofia 97, Catania, Italy. (författare)
  • Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419 (författare)
  • Cryan, JohnUniv Coll Cork, Anat & Neurosci, 386 Western Gateway Bldg, Cork, Ireland. (författare)
  • Dye, LouiseUniv Leeds, Sch Psychol, Human Appetite Res Unit, Leeds LS2 9JT, W Yorkshire, England. (författare)
  • Farrimond, Jonathan A.Lucozade Ribena Suntory Ltd, Uxbridge, Middx, England. (författare)
  • Korosi, AnikoUniv Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands. (författare)
  • Laye, SophieINRA Bordeaux Univ, Nutr & Neurobiol Integree, 146 Rue Lio Saignat, F-33076 Bordeaux, France. (författare)
  • Maudsley, StuartUniv Antwerp, Dept Biomed Res, Gebouw V,Campus Drie Eileen,Univ Pl 1, Antwerp, Belgium.;Univ Antwerp, VIBU Antwerp Ctr Mol Neurol, Gebouw V,Campus Drie Eileen,Univ Pl 1, Antwerp, Belgium. (författare)
  • Milenkovic, DraganUCA, INRA, Human Nutr Unit, F-63003 Clermont Ferrand, France.;Univ Calif Davis, Sch Med, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA. (författare)
  • Mohajeri, M. HasanDSM Nutr Prod Ltd, Wurmisweg 576, CH-4303 Kaiseraugst, Switzerland. (författare)
  • Sijben, JohnNutr Adv Med Nutr, Nutr Res, POB 80141, NL-3508 TC Utrecht, Netherlands. (författare)
  • Solomon, AlinaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Inst, Aging Res Ctr, Gavlegatan 16, SE-11330 Stockholm, Sweden. (författare)
  • Spencer, Jeremy P. E.Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Dept Food & Nutr Sci, Reading RG6 6AP, Berks, England. (författare)
  • Thuret, SandrineKings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Clin Neurosci Inst, 125 Coldharbour Lane, London SE5 9NU, England. (författare)
  • Vanden Berghe, WimUniv Antwerp, Dept Biomed Sci, PPES, Campus Drie Eileen,Univ Pl 1, B-2610 Antwerp, Belgium. (författare)
  • Vauzour, DavidUniv East Anglia, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England. (författare)
  • Vellas, BrunoCHU Toulouse, Dept Geriatr Med, Toulouse, France. (författare)
  • Wesnes, KeithWesnes Cognit Ltd, Little Paddock, Streatley On Thames RG8 9RD, England.;Univ Exeter, Med Sch, Exeter, Devon, England.;Northumbria Univ, Dept Psychol, Newcastle, NSW, Australia.;Swinbume Univ, Ctr Human Psychopharmacol, Melbourne, Vic, Australia.;Newcastle Univ, Med Plant Res Croup, Newcastle, NSW, Australia. (författare)
  • Willatts, PeterUniv Dundee Nethergate, Sch Psychol, Dundee DD1 4HN, Scotland. (författare)
  • Wittenberg, RaphaelLondon Sch Econ & Polit Sci, Personal Social Serv, Res Unit, London, England. (författare)
  • Geurts, LucieEurope ILSI Europe, Int Life Sci Inst, E Mounier 83,Box 6, B-1200 Brussels, Belgium. (författare)
  • Mars Wrigley, 1132 W Blackhawk St, Chicago, IL 60642 USA.Univ Leeds, Sch Psychol, Human Appetite Res Unit, Leeds LS2 9JT, W Yorkshire, England. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Ageing Research Reviews: Elsevier BV42, s. 40-551568-16371872-9649

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