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  • Franco, IreneKarolinska Institutet,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (author)

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-23
  • Springer Science and Business Media LLC,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-154850
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-154850URI
  • https://doi.org/10.1038/s41467-018-03244-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137714162URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-348850URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-145756URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council; Center for Innovative Medicine; Hagelen Foundation; Osterman Foundation; Svenska Lakaresallskapet; Stohnes Foundation; INFERNET [734439]; Swedish Medical Research Council [2013-09305]; Marcus and Marianne Wallenberg foundation; Wallenberg Foundation; Science for Life Laboratory; Knut and Alice Wallenberg Foundation; National Genomics Infrastructure - the Swedish Research Council; Mutation Analysis Core Facility (MAF) at the Karolinska University Hospital
  • Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. To study the connection between SC aging and muscle impairment, we analyze the whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21-78 years). We find an accumulation rate of 13 somatic mutations per genome per year, consistent with proliferation of SCs in the healthy adult muscle. SkM-expressed genes are protected from mutations, but aging results in an increase in mutations in exons and promoters, targeting genes involved in SC activity and muscle function. In agreement with SC mutations affecting the whole tissue, we detect a missense mutation in a SC propagating to the muscle. Our results suggest somatic mutagenesis in SCs as a driving force in the age-related decline of SkM function.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Johansson, Anna C. V.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär evolution,Uppsala Univ, Sweden(Swepub:uu)anjoh226 (author)
  • Olsson, KarlKarolinska Institutet,Karolinska Inst, Dept Lab Med, Div Clin Physiol, S-14186 Huddinge, Sweden. (author)
  • Vrtačnik, PeterKarolinska Institutet,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (author)
  • Lundin, PärStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Karolinska Institutet, Sweden,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden.;Stockholm Univ, DBB, Sci Life Lab, S-10691 Stockholm, Sweden.(Swepub:su)prlu0183 (author)
  • Helgadottir, Hafdis T.Karolinska Institutet,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (author)
  • Larsson, MalinLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)malla74 (author)
  • Revêchon, GwladysKarolinska Institutet,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (author)
  • Bosia, CarlaIIGM, I-10126 Turin, Italy.;Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy. (author)
  • Pagnani, AndreaIIGM, I-10126 Turin, Italy.;Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy. (author)
  • Provero, PaoloMol Biotechnol Ctr, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy.;Ist Sci San Raffaele, Ctr Translat Genom & Bioinformat, I-20132 Milan, Italy. (author)
  • Gustafsson, ThomasKarolinska Institutet,Karolinska Inst, Sweden (author)
  • Fischer, HeleneKarolinska Institutet,Karolinska Inst, Sweden (author)
  • Eriksson, MariaKarolinska Institutet,Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (author)
  • Karolinska InstitutetKarolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, S-14157 Huddinge, Sweden. (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC92041-1723

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