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CD161 Defines a Fun...
CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells
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Kurioka, Ayako (author)
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Cosgrove, Cormac (author)
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Simoni, Yannick (author)
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van Wilgenburg, Bonnie (author)
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Geremia, Alessandra (author)
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- Björkander, Sophia (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Sverremark-Ekström, Eva (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Thurnheer, Christine (author)
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Günthard, Huldrych F. (author)
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Khanna, Nina (author)
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Walker, Lucy Jane (author)
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Arancibia-Cárcamo, Carolina V. (author)
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Newell, Evan W. (author)
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Willberg, Christian B. (author)
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Klenerman, Paul (author)
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(creator_code:org_t)
- 2018-04-09
- 2018
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 9
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- natural killer cells
- CD161
- pro-inflammatory cytokines
- cytomegalovirus
- human immunodeficiency virus
- inflammatory bowel diseases
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kurioka, Ayako
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Cosgrove, Cormac
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Simoni, Yannick
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van Wilgenburg, ...
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Geremia, Alessan ...
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Björkander, Soph ...
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show more...
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Sverremark-Ekstr ...
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Thurnheer, Chris ...
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Günthard, Huldry ...
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Khanna, Nina
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Walker, Lucy Jan ...
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Arancibia-Cárcam ...
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Newell, Evan W.
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Willberg, Christ ...
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Klenerman, Paul
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Stockholm University