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Effect of the NU-AG...
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Marseglia, AnnaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(författare)
Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-04-04
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Frontiers Media SA,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:su-155957
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-155957URI
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https://doi.org/10.3389/fphys.2018.00349DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137975794URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE's dietary intervention on age related cognitive decline.Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65-79 years, from five European centers. Participants were randomly allocated into two groups: control (n = 638), following a habitual diet; and, intervention (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD total score), and five cognitive domains (perceptual speed, executive function, episodic memory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed effects models.Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from the intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [beta 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [beta 0.15 (95%Cl 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.
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Xu, WeiliKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China
(författare)
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Fratiglioni, LauraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
(författare)
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Fabbri, Cristina
(författare)
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Berendsen, Agnes A. M.
(författare)
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Bialecka-Debek, Agata
(författare)
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Jennings, Amy
(författare)
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Gillings, Rachel
(författare)
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Meunier, Nathalie
(författare)
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Caumon, Elodie
(författare)
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Fairweather-Tait, Susan
(författare)
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Pietruszka, Barbara
(författare)
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De Groot, Lisette C. P. G. M.
(författare)
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Santoro, Aurelia
(författare)
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Franceschi, Claudio
(författare)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
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Ingår i:Frontiers in Physiology: Frontiers Media SA91664-042X
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Marseglia, Anna
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Xu, Weili
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Fabbri, Cristina
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Berendsen, Agnes ...
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Jennings, Amy
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Gillings, Rachel
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Meunier, Nathali ...
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Caumon, Elodie
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Pietruszka, Barb ...
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De Groot, Lisett ...
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Santoro, Aurelia
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