Chemoselective Iridium-catalysed Peterson olefination/Asymmetric Hydrogenation of beta-Hydroxy Silaned

• Herein we report the use of Ir-N,P catalysts for the asymmetric hydrogenation of β-hydroxy silanes via an in-situ generated olefin intermediate. The reaction proceeds via an acid catalysed Peterson olefination reaction and provides hydrogenated products in excellent ee’s of up to 99% accompanied with high isolated yields under mild reaction conditions and short reaction times. Modification of the reaction conditions provides a choice to hydrogenate either an olefin or a β-hydroxy silane in a chemo-selective manner leaving the other functionality unaffected in the product.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

Peterson Olefination

organisk kemi

Organic Chemistry

Publikations- och innehållstyp

vet (ämneskategori)

ovr (ämneskategori)