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Disruption of A2AR-...
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Borroto-Escuela, Dasiel O.Karolinska Institutet
(författare)
Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-01-30
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Springer Science and Business Media LLC,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-159011
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-159011URI
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https://doi.org/10.1007/s12035-018-0887-1DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362042URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138847967URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Antagonistic allosteric A2AR-D2R receptor-receptor interactions in heteroreceptor complexes counteract cocaine self-administration and cocaine seeking in rats as seen in biochemical and behavioral experiments. It was shown that the human A2AR transmembrane five (TM5) was part of the interface of the human A2AR-D2R receptor heteromer. In the current paper, the rat A2AR synthetic TM5 (synthTM5) peptide disrupts the A2AR-D2R heteroreceptor complex in HEK293 cells as shown by the bioluminescence resonance energy transfer method. Rat A2AR synthTM5 peptide, microinjected into the nucleus accumbens, produced a complete counteraction of the inhibitory effects of the A2AR agonist CGS21680 on cocaine self-administration. It was linked to a disappearance of the accumbal A2AR-D2R heteroreceptor complexes and the A2AR agonist induced inhibition of D2R recognition using proximity ligation assay and biochemical binding techniques. However, possible effects of the A2AR synthTM5 peptide on accumbal A2AR-D3R and A2AR-D4R heteroreceptor complexes remain to be excluded. Evidence is provided that accumbal A2AR-D2R-like heteroreceptor complexes with their antagonistic receptor-receptor interactions can be major targets for treatment of cocaine use disorder.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wydra, KarolinaPolish Acad Sci, Inst Pharmacol, Dept Drug Addict Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland
(författare)
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Li, XiangJilin Univ, Coll Life Sci, Qianjin St 2699, Changchun 130012, Jilin, Peoples R China;Karolinska Inst, Dept Neurosci, Retzius Vag 8, S-17177 Stockholm, Sweden
(författare)
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Rodriguez, DavidUppsala universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Uppsala University BMC, Sweden,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab,Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-10691 Stockholm, Sweden
(författare)
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Carlsson, JensUppsala universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Uppsala University BMC, Sweden,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab,Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, SE-10691 Stockholm, Sweden(Swepub:uu)jecar425
(författare)
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Jastrzebska, JoannaPolish Acad Sci, Inst Pharmacol, Dept Drug Addict Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland
(författare)
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Filip, MalgorzataPolish Acad Sci, Inst Pharmacol, Dept Drug Addict Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland
(författare)
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Fuxe, KjellKarolinska Institutet
(författare)
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Karolinska InstitutetPolish Acad Sci, Inst Pharmacol, Dept Drug Addict Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Neurobiology: Springer Science and Business Media LLC55:8, s. 7038-70480893-76481559-1182
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