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  • Binder, Zev A.Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA. (author)

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier BV,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-159114
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-159114URI
  • https://doi.org/10.1016/j.ccell.2018.06.006DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232613URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20180730
  • We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with EGFR mutations at alanine 289 (EGFR(A289D/T/V)). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased tumor invasion for EGFR(A289D/T/V) mutants, corroborated in mice bearing intracranial tumors expressing EGFR(A289V) and dependent on ERK-mediated expression of matrix metalloproteinase-1. EGFR(A289V) tumor growth was attenuated with an antibody against a cryptic epitope, based on in silico simulation. The findings of this study indicate a highly invasive phenotype associated with the EGFR(A289V) mutation in glioblastoma, postulating EGFR(A289V) as a molecular marker for responsiveness to therapy with EGFR-targeting antibodies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Haseley Thorne, AmyLudwig Inst Canc Res, San Diego, CA 92093 USA. (author)
  • Bakas, SpyridonUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA. (author)
  • Wileyto, E. PaulUniv Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA. (author)
  • Bilello, MichelUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA. (author)
  • Akbari, HamedUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA. (author)
  • Rathore, SaimaUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA. (author)
  • Ha, Sung MinUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA. (author)
  • Zhang, LoganUniv Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA. (author)
  • Ferguson, Cole J.Washington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA. (author)
  • Dahiya, SonikaWashington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA. (author)
  • Bi, Wenya LindaBrigham & Womans Hosp, Harvard Med Ctr, Dept Neurosurg, Ctr Skull Base & Pituitary Surg, Boston, MA 02115 USA. (author)
  • Reardon, David A.Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02215 USA. (author)
  • Idbaih, AhmedSorbonne Univ, Hop Univ Pitie Salpetriere Charles Foix, AP HP, Serv Neurol Mazarin 2, Inserm,CNRS,UMR S 1127, F-75013 Paris, France. (author)
  • Felsberg, JoergHeinrich Heine Univ, Inst Neuropathol, Med Fac, Moorenstr 5, D-40225 Dusseldorf, Germany. (author)
  • Hentschel, BettinaUniv Leipzig, Med Fac, Inst Med Informat Stat & Epidemiol, Hartelstr 16, D-04107 Leipzig, Germany. (author)
  • Weller, MichaelUniv Hosp, Dept Neurol, CH-8091 Zurich, Switzerland.;Univ Zurich, CH-8091 Zurich, Switzerland. (author)
  • Bagley, Stephen J.Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. (author)
  • Morrissette, Jennifer J. D.Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA. (author)
  • Nasrallah, MacLean P.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Div Neuropathol, Philadelphia, PA 19104 USA. (author)
  • Ma, Jianhui (author)
  • Zanca, Ciro (author)
  • Scott, Andrew M.La Trobe Univ, Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia. (author)
  • Orellana, LauraKTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, SciLifeLab,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden(Swepub:kth)u107xt9t (author)
  • Davatzikos, Christos (author)
  • Furnari, Frank B.Ludwig Inst Canc Res, San Diego, CA 92093 USA. (author)
  • O'Rourke, Donald M.Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. (author)
  • Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.Ludwig Inst Canc Res, San Diego, CA 92093 USA. (creator_code:org_t)

Related titles

  • In:Cancer Cell: Elsevier BV34:1, s. 163-1771535-61081878-3686

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