WFRF:(Galmozzi Andrea)
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- Galmozzi, Andrea (author)
ThermoMouse : An In Vivo Model to Identify Modulators of UCP1 Expression in Brown Adipose Tissue
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- Elsevier BV,2014
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-163375
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-163375URI
- https://doi.org/10.1016/j.celrep.2014.10.066DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Obesity develops when energy intake chronically exceeds energy expenditure. Because brown adipose tissue (BAT) dissipates energy in the form of heat, increasing energy expenditure by augmenting BAT-mediated thermogenesis may represent an approach to counter obesity and its complications. The ability of BAT to dissipate energy is dependent on expression of mitochondrial uncoupling protein 1 (UCP1). To facilitate the identification of pharmacological modulators of BAT UCP1 levels, which may have potential as antiobesity medications, we developed a transgenic model in which luciferase activity faithfully mimics endogenous UCP1 expression and its response to physiologic stimuli. Phenotypic screening of a library using cells derived from this model yielded a small molecule that increases UCP1 expression in brown fat cells and mice. Upon adrenergic stimulation, compound-treated mice showed increased energy expenditure. These tools offer an opportunity to identify pharmacologic modulators of UCP1 expression and uncover regulatory pathways that impact BAT-mediated thermogenesis.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- UCP1
- brown adipose tissue
- mouse model
- screening
- Luciferase
- Molecular Cellbiology
- molekylär cellbiologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Sonne, Si B. (author)
- Altshuler-Keylin, Svetlana (author)
- Hasegawa, Yutaka (author)
- Shinoda, Kosaku (author)
- Luijten, Ineke H. N.,1989-University of California, USA(Swepub:su)inlu1142 (author)
- Won Chang, Jae (author)
- Sharp, Louis Z. (author)
- Cravatt, Benjamin F. (author)
- Saez, Enrique (author)
- Kajimura, Shingo (author)
- University of California, USA (creator_code:org_t)
Related titles
- In:Cell Reports: Elsevier BV9:5, s. 1584-15932211-1247
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- Cell Reports
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- Stockholm University
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