Hypertension and frailty: a systematic review and meta-analysis

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Vetrano, Davide L.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Università Cattolica del Sacro Cuore, Italy (author)

Hypertension and frailty : a systematic review and meta-analysis

Article/chapterEnglish2018

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2018-12-28
BMJ,2018
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LIBRIS-ID:oai:DiVA.org:su-165719
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-165719URI
https://doi.org/10.1136/bmjopen-2018-024406DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140019615URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

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Objective To review the association between hypertension and frailty in observational studies. Design A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension. Setting, participants and measures Studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of hypertension and frailty were included. Results Among the initial 964 articles identified, 27 were included in the review. Four longitudinal studies examined the incidence of frailty according to baseline hypertension status, providing conflicting results. Twenty-three studies assessed the cross-sectional association between frailty and hypertension: 13 of them reported a significantly higher prevalence of frailty in hypertensive participants and 10 found no significant association. The pooled prevalence of hypertension in frail individuals was 72% (95% CI 66% to 79%) and the pooled prevalence of frailty in individuals with hypertension was 14% (95% CI 12% to 17%). Five studies, including a total of 7656 participants, reported estimates for the association between frailty and hypertension (pooled OR 1.33; 95% CI 0.94 to 1.89). Conclusions Frailty is common in persons with hypertension. Given the possible influence of frailty on the risk-benefit ratio of treatment for hypertension and its high prevalence, it is important to assess the presence of this condition in persons with hypertension.

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Palmer, Katie M. (author)
Galluzzo, Lucia (author)
Giampaoli, Simona (author)
Marengoni, Alessandra (author)
Bernabei, Roberto (author)
Onder, Graziano (author)
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

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In:BMJ Open: BMJ8:122044-6055

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Other Medical an ...; and Gerontology spec ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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