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- Kjellsson Lindblom, EmelyStockholms universitet,Fysikum,Stockholm Univ, Sweden (author)
Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-05-15
- Anticancer Research USA Inc.2019
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:su-168923
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-168923URI
- https://doi.org/10.21873/anticanres.13350DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:141046788URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158344URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396587URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Funding Agencies|Cancer Research Funds of Radiumhemmet (Solna, Sweden)
- Background/Aim: This study investigated the impact of temporary vascular collapse on tumour control probability (TCP) in stereotactic body radiotherapy (SBRT), taking into account different radiosensitivities of chronically and acutely hypoxic cells. Materials and Methods: Three-dimensional tumours with heterogeneous oxygenation were simulated assuming different fractions of collapsed vessels at every treatment fraction. The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction ≤5 mm Hg of 30-50%. The rest of the tumours were well-oxygenated at the start of the simulated treatment. Results: For all simulated cases, the largest reduction in TCP from 97% to 2% was found in a tumour with a small chronically hypoxic core treated with 60 Gy in eight fractions and assuming a treatment-induced vascular collapse of 35% in the well-oxygenated region. Conclusion: The timing of SBRT fractions should be considered together with the tumour oxygenation to avoid loss of TCP in SBRT.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- NATURVETENSKAP Fysik hsv//swe
- NATURAL SCIENCES Physical Sciences hsv//eng
- Hypoxia
- vascular damage
- stereotactic body radiotherapy
- SBRT
- tumour control probability
- TCP
- tumour oxygenation
Added entries (persons, corporate bodies, meetings, titles ...)
- Dasu, AlexandruLinköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Skandion Clin, Sweden(Swepub:uu)aleda511 (author)
- Toma-Dasu, IulianaKarolinska Institutet,Stockholms universitet,Fysikum,Karolinska Institute, Sweden,Stockholm Univ, Sweden; Karolinska Inst, Sweden(Swepub:su)iuda0736 (author)
- Stockholms universitetFysikum (creator_code:org_t)
Related titles
- In:Anticancer Research: Anticancer Research USA Inc.39:5, s. 2337-23400250-70051791-7530
Internet link
- https://doi.org/10.21873/anticanres.13350Fulltext
- http://ar.iiarjournals.org/content/39/5/2337.full.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-168923
- https://doi.org/10.21873/anticanres.13350
- http://kipublications.ki.se/Default.aspx?queryparsed=id:141046788
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158344
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396587
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