Membrane-mimetic systems for biophysical studies of the amyloid-beta peptide

• The interplay between the amyloid-beta (A beta) peptide and cellular membranes have been proposed as an important mechanism for toxicity in Alzheimer's disease (AD). Membrane environments appear to influence A beta aggregation and may stabilize intermediate A beta oligomeric states that are considered to be neurotoxic. One important role for molecular biophysics within the field of A beta studies is to characterize the structure and dynamics of the A beta peptide in various states, as well as the kinetics of transfer between these states. Because biological cell membranes are very complex, simplified membrane models are needed to facilitate studies of A beta and other amyloid proteins in lipid environments. In this review, we examine different membrane-mimetic systems available for molecular studies of A beta. An introduction to each system is given, and examples of important findings are presented for each system. The benefits and drawbacks of each system are discussed from methodical and biological perspectives.

Ämnesord

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Alzheimer's disease

Amyloid

Protein aggregation

Protein-membrane interaction

Biomembranes

Protein spectroscopy

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)