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Alpinia zerumbet (P...
Alpinia zerumbet (Pers.) : Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
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- Zahra, Maram Hussein (författare)
- Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Okayama 7008530, Japan
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- Salem, Tarek A. R. (författare)
- Qassim Univ, Dept Biochem, Coll Med, Al Qassim 51452, Saudi Arabia;Univ Sadat City, Genet Engn & Biotechnol Inst, Dept Mol Biol, Sadat City 32958, Egypt,Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
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- El-Aarag, Bishoy (författare)
- Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Okayama 7008530, Japan;Menoufia Univ, Div Biochem, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
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- Yosri, Nermeen (författare)
- Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
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- EL-Ghlban, Samah (författare)
- Menoufia Univ, Div Biochem, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
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- Zaki, Kholoud (författare)
- Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
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- Marei, Amel H. (författare)
- Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
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- Abd El-Wahed, Aida (författare)
- Uppsala universitet,Farmakognosi,Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt;Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt
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Saeed, Aamer (författare)
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- Khatib, Alfi (författare)
- Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Fac Pharm, Kuantan 25200, Pahang, Malaysia
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- AlAjmi, Mohamed F. (författare)
- King Saud Univ, Coll Pharm, Pharmacognosy Grp, Riyadh 11451, Saudi Arabia
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- Shathili, Abdulrahman M. (författare)
- Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia
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- Xiao, Jianbo (författare)
- Univ Macau, Inst Chinese Med Sci, Taipa 999078, Macau, Peoples R China
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- Khalifa, Shaden A. M. (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Clin Res Ctr, S-14186 Huddinge, Sweden;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt;Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia;Jiangsu Univ, Coll Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China
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(creator_code:org_t)
- 2019-07-08
- 2019
- Engelska.
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Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 24:13
- Relaterad länk:
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https://doi.org/10.3...
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https://europepmc.or...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, H-1-NMR and C-13-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 mu g/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Alpinia zerumbet
- 5
- 6-dehydrokawain
- Ehrlich ascites carcinoma
- anti-tumor
- anti-oxidant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zahra, Maram Hus ...
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Salem, Tarek A. ...
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El-Aarag, Bishoy
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Yosri, Nermeen
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EL-Ghlban, Samah
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Zaki, Kholoud
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visa fler...
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Marei, Amel H.
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Abd El-Wahed, Ai ...
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Saeed, Aamer
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Khatib, Alfi
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AlAjmi, Mohamed ...
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Shathili, Abdulr ...
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Xiao, Jianbo
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Khalifa, Shaden ...
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El-Seedi, Hesham
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Molecules
- Av lärosätet
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Stockholms universitet
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Uppsala universitet