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Marine Natural Prod...
Marine Natural Products : A Source of Novel Anticancer Drugs
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- Khalifa, Shaden A. M. (författare)
- Uppsala universitet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Clin Res Ctr, S-14157 Stockholm, Sweden;Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, SE-10691 Stockholm, Sweden,Kuwait Univ, Dept Chem, Fac Sci, Safat 13060, Kuwait,Farmakognosi
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- Elias, Nizar (författare)
- Univ Kalamoon, Dept Lab Med, Fac Med, POB 222, Dayr Atiyah, Syria
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- Farag, Mohamed A. (författare)
- Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt;Amer Univ Cairo, Dept Chem, Sch Sci & Engn, New Cairo 11835, Egypt
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- Chen, Lei (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China
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- Saeed, Aamer (författare)
- Quaid I Azam Univ, Dept Chemitry, Islamabad 45320, Pakistan
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- Hegazy, Mohamed-Elamir F. (författare)
- Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Staudingerweg 5, D-55128 Mainz, Germany;Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt
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- Moustafa, Moustafa S. (författare)
- Kuwait Univ, Dept Chem, Fac Sci, Safat 13060, Kuwait
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- Abd El-Wahed, Aida (författare)
- Kuwait Univ, Dept Chem, Fac Sci, Safat 13060, Kuwait
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Al-Mousawi, Saleh M. (författare)
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- Musharraf, Syed G. (författare)
- Univ Karachi, Int Ctr Chem & Biol Sci ICCBS, HEJ Inst Chem Res, Karachi 75270, Pakistan
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- Chang, Fang-Rong (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
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- Iwasaki, Arihiro (författare)
- Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan
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- Suenaga, Kiyotake (författare)
- Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan;Univ HalleWittenberg, Dept Pharmaceut Biol Pharmacognosy, Inst Pharm, Hoher Weg 8, DE-06120 Halle, Saale, Germany
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Alajlani, Muaaz (författare)
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- Göransson, Ulf, 1970- (författare)
- Uppsala universitet,Farmakognosi
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt;Jiangsu Univ, Coll Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China;Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia
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(creator_code:org_t)
- 2019-08-23
- 2019
- Engelska.
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Ingår i: Marine Drugs. - : MDPI AG. - 1660-3397. ; 17:9
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- marine
- plants
- microorganism
- antitumor
- anticancer
- cytotoxic
- clinical trials
- drugs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Khalifa, Shaden ...
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Elias, Nizar
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Farag, Mohamed A ...
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Chen, Lei
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Saeed, Aamer
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Hegazy, Mohamed- ...
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Moustafa, Mousta ...
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Abd El-Wahed, Ai ...
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Al-Mousawi, Sale ...
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Musharraf, Syed ...
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Chang, Fang-Rong
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Iwasaki, Arihiro
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Suenaga, Kiyotak ...
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Alajlani, Muaaz
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Göransson, Ulf, ...
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El-Seedi, Hesham
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmakologi och ...
- Artiklar i publikationen
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Marine Drugs
- Av lärosätet
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Stockholms universitet
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Uppsala universitet