Bile acids adsorption by chitoan-fumed silica enterosorbent

• Hybrid composites from chitosan and fumed silica were synthesized and applied for the adsorption of bile acids (BA), e.g. cholic (CA) and taurocholic (TCA) acids. The chitosan immobilization was confirmed by infrared spectroscopy and the corresponding stability of the composites was confirmed by tests with the analytical reagent ninhydrin. The effects of adsorption parameters such as initial concentration of BA and pH were evaluated. The synthesized composite shows higher affinity and adsorption capacity toward TCA in comparison to CA. The results of equilibrium study for BA adsorption by the synthesized composite were analyzed by application of Langmuir, Freundlich and Temkin isotherm models. Adsorption capacity of chitosan-fumed silica composite was 97 mu mol/g for TCA and 43 mu mol/g for CA based on the applied Freundlich isoterm model. Our results show the potential of biopolymeric-inorganic composites for application as efficient enterosorbent in medical practice.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Bile acids

Chitosan

Silica

Enterosorbent

Cholic acid

Taurocholic acid

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)