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Activation of Kappa...
Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss
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Cintron-Colon, Rigo (author)
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Johnson, Christopher W. (author)
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Montenegro-Burke, J. Rafael (author)
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Guijas, Carlos (author)
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Faulhaber, Lila (author)
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Sanchez-Alavez, Manuel (author)
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Aguirre, Carlos A. (author)
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Shankar, Kokila (author)
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Singh, Mona (author)
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Galmozzi, Andrea (author)
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Siuzdak, Gary (author)
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Saez, Enrique (author)
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- Conti, Bruno (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,The Scripps Research Institute, USA
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 29:24, s. 4291-4299
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Mammals maintain a nearly constant core body temperature (T-b) by balancing heat production and heat dissipation. This comes at a high metabolic cost that is sustainable if adequate calorie intake is maintained. When nutrients are scarce or experimentally reduced such as during calorie restriction (CR), endotherms can reduce energy expenditure by lowering T-b [1-6]. This adaptive response conserves energy, limiting the loss of body weight due to low calorie intake [710]. Here we show that this response is regulated by the kappa opioid receptor (KOR). CR is associated with increased hypothalamic levels of the endogenous opioid Leuenkephalin, which is derived from the KOR agonist precursor dynorphin [11]. Pharmacological inhibition of KOR, but not of the delta or the mu opioid receptor subtypes, fully blocked CR-induced hypothermia and increased weight loss during CR independent of calorie intake. Similar results were seen with DIO mice subjected to CR. In contrast, inhibiting KOR did not change T-b in animals fed ad libitum (AL). Chemogenetic inhibition of KOR neurons in the hypothalamic preoptic area reduced the CR-induced hypothermia, whereas chemogenetic activation of prodynorphin-expressing neurons in the arcuate or the parabrachial nucleus lowered T-b. These data indicate that KOR signaling is a pivotal regulator of energy homeostasis and can affect body weight during dieting by modulating T-b and energy expenditure.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cintron-Colon, R ...
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Johnson, Christo ...
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Montenegro-Burke ...
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Guijas, Carlos
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Faulhaber, Lila
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Sanchez-Alavez, ...
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show more...
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Aguirre, Carlos ...
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Shankar, Kokila
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Singh, Mona
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Galmozzi, Andrea
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Siuzdak, Gary
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Saez, Enrique
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Conti, Bruno
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Current Biology
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Stockholm University