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Handling ties in co...
Handling ties in continuous outcomes for confounder adjustment with rank-ordered logit and its application to ordinal outcomes
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- Ning, Yilin (author)
- National University of Singapore, Singapore
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- Tan, Chuen Seng (author)
- National University of Singapore, Singapore
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- Maraki, Angeliki (author)
- Stockholms universitet,Matematiska institutionen,Stockholm University, Stockholm, Sweden
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- Ho, Peh Joo (author)
- National University of Singapore, Singapore
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- Hodgins, Sheilagh (author)
- Université de Montréal, Montréal, Canada
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- Comasco, Erika, 1982- (author)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Nilsson, Kent W. (author)
- Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Wagner, Philippe (author)
- Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Khoo, Eric Y. H. (author)
- National University of Singapore, National University Health System, Singapore
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- Tai, E-Shyong (author)
- National University of Singapore, National University Health System, Singapore
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- Kao, Shih Ling (author)
- National University of Singapore, National University Health System, Singapore
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- Hartman, Mikael (author)
- National University of Singapore, Singapore
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- Reilly, Marie (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Støer, Nathalie C. (author)
- Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2019-04-03
- 2020
- English.
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In: Statistical Methods in Medical Research. - : SAGE Publications. - 0962-2802 .- 1477-0334. ; 29:2, s. 437-454
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https://doi.org/10.1...
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Abstract
Subject headings
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- The rank-ordered logit (rologit) model was recently introduced as a robust approach for analysing continuous outcomes, with the linear exposure effect estimated by scaling the rank-based log-odds estimate. Here we extend the application of the rologit model to continuous outcomes with ties and ordinal outcomes treated as imperfectly-observed continuous outcomes. By identifying the functional relationship between survival times and continuous outcomes, we explicitly establish the equivalence between the rologit and Cox models to justify the use of the Breslow, Efron and perturbation methods in the analysis of continuous outcomes with ties. Using simulation, we found all three methods perform well with few ties. Although an increasing extent of ties increased the bias of the log-odds and linear effect estimates and resulted in reduced power, which was somewhat worse when the model was mis-specified, the perturbation method maintained a type I error around 5%, while the Efron method became conservative with heavy ties but outperformed Breslow. In general, the perturbation method had the highest power, followed by the Efron and then the Breslow method. We applied our approach to three real-life datasets, demonstrating a seamless analytical workflow that uses stratification for confounder adjustment in studies of continuous and ordinal outcomes.
Subject headings
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Rank-ordered logit model
- stratification
- tied observations
- continuous outcome
- ordinal outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ning, Yilin
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Tan, Chuen Seng
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Maraki, Angeliki
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Ho, Peh Joo
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Hodgins, Sheilag ...
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Comasco, Erika, ...
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show more...
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Nilsson, Kent W.
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Wagner, Philippe
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Khoo, Eric Y. H.
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Tai, E-Shyong
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Kao, Shih Ling
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Hartman, Mikael
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Reilly, Marie
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Støer, Nathalie ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Mathematics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Statistical Meth ...
- By the university
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Stockholm University
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Uppsala University
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Karolinska Institutet
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Mälardalen University